254115-97-4Relevant academic research and scientific papers
Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands
Haubmann, Christian,Huebner, Harald,Gmeiner, Peter
, p. 3143 - 3146 (2007/10/03)
Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knorr reaction. For the introduction of pyrrole-substituents high yielding transformations including Sonogashira cross-coupling reactions were utilized. Employment of the reagent TosMIC gave access to the regioisomeric oxazolyl derivatives 7 and 11 which showed the highest dopamine D4 receptor binding of the series investigated.
