2543-94-4 Usage
General Description
Phellopterin is a natural chemical compound extracted from plants belonging to the Rutaceae family. This coumarin derivative exhibits various biological activities including anti-inflammatory, bronchodilating, and anti-spasmodic properties. Some research also indicates potential antiviral activity of phellopterin. Despite its beneficial effects, the compound may have some cytotoxic side effects. The compound is not synthesized industrially and is usually obtained directly from plant sources. Its structure includes a benzopyrone core, characteristic of coumarins.
Check Digit Verification of cas no
The CAS Registry Mumber 2543-94-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,4 and 3 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2543-94:
(6*2)+(5*5)+(4*4)+(3*3)+(2*9)+(1*4)=84
84 % 10 = 4
So 2543-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H16O5/c1-10(2)6-8-21-17-15-12(7-9-20-15)14(19-3)11-4-5-13(18)22-16(11)17/h4-7,9H,8H2,1-3H3
2543-94-4Relevant articles and documents
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor
Marumoto, Shinsuke,Miyazawa, Mitsuo
supporting information; experimental part, p. 784 - 788 (2012/03/22)
The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.
