2543-94-4 Usage
Uses
Used in Pharmaceutical Industry:
Phellopterin is used as a therapeutic agent for its anti-inflammatory, bronchodilating, and anti-spasmodic properties, which can be beneficial in treating various respiratory and inflammatory conditions.
Used in Antiviral Applications:
Phellopterin is used as a potential antiviral agent due to some research indicating its antiviral activity, which could be explored for the development of treatments against viral infections.
Used in Research and Development:
Phellopterin is used as a subject of research for further exploration of its biological activities and potential applications in medicine, given its diverse pharmacological properties and the possibility of mitigating its cytotoxic side effects through formulation or delivery methods.
Check Digit Verification of cas no
The CAS Registry Mumber 2543-94-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,4 and 3 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2543-94:
(6*2)+(5*5)+(4*4)+(3*3)+(2*9)+(1*4)=84
84 % 10 = 4
So 2543-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H16O5/c1-10(2)6-8-21-17-15-12(7-9-20-15)14(19-3)11-4-5-13(18)22-16(11)17/h4-7,9H,8H2,1-3H3
2543-94-4Relevant academic research and scientific papers
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor
Marumoto, Shinsuke,Miyazawa, Mitsuo
supporting information; experimental part, p. 784 - 788 (2012/03/22)
The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.
