25434-84-8

Upstream product

• 21139-32-2 ethyl 3-phenyl-5-chloroindole-2-carboxylate 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 24139-99-9 ethyl 2-[2-(4-chlorophenyl)hydrazinylidene]-3-phenylpropanoate 

Downstream Products

• 120607-51-4 2-(5-Chloro-3-phenyl-1H-indole-2-carbonyl)-5-methyl-2,4-dihydro-pyrazol-3-one 
• 121649-92-1 1-phenyl-3-(5'-chloro-3'-phenyl-indole-2'-carboxamido)-thiourea 
• 120636-53-5 5-Chloro-3-phenyl-1H-indole-2-carboxylic acid [1-phenyl-eth-(E)-ylidene]-hydrazide 
• 120607-42-3 (5-Chloro-3-phenyl-1H-indol-2-yl)-(3,5-dimethyl-pyrazol-1-yl)-methanone 
• 70070-30-3 5-chloro-3-phenyl-1H-indol-2-carbonyl azide 
• 166328-86-5 5-chloro-3-phenyl-2-(5'-thioxo-1',3',4'-oxadiazol-2'-yl)indole 
• 316156-12-4 3-[N'-(5-chloro-3-phenyl-1H-indole-2-carbonyl)-hydrazino]-3-oxo-propionic acid ethyl ester 
• 1251943-53-9 C₂₆H₁₉ClN₄O₂ 
• 1251943-52-8 C₂₅H₁₇ClN₄O₂ 

Relevant academic research and scientific papers

Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives

Abstract: A series of indole-based spirothiazolidinones have been designed, synthesized and evaluated, in vitro, for their antitubercular, antiviral, antibacterial, and antifungal activities. The structures of the new compounds were established by IR, su

Synthesis and biological activities of new 3,5-disubstituted -2-(ethyl- 5'-thioxo-1',3',4'-oxadiazol-4'-ethylacetate-2'-yl) indoles,-2-(5'-thioxo- 1',3',4'-oxadiazol-4'-methylcarboxyhydrazide-2'-yl) indoles and -2-(5'- thioxo-1',3',4'-oxadiazol-4'-alkyl-2

3,5-Disubstituted indole-2-carboxylates 1a-g are reacted with hydrazine hydrate to furnish the corresponding indole-2-carboxyhydrazides 2a-g These on reaction with alkaline carbon disulphide under thermal reaction conditions produce respective 2-(5'-thiox

Synthesis of Substituted 1,2,3,8-Tetrahydroindolobenzodiazepin-2-ones and 5,6,7,8-Tetrahydroindolobenzodiazepin-6-ones

Nitrosation (NaNO2/AcOH) of 2-phenylindoles (1a-d) and subsequent reduction of the resultant 3-nitroso-2-phenylindoles (2a-d) with sodium dithionite in alkali furnish the corresponding 3-aminoindoles (3a-d), which on condensation with ethyl chloroformate

Synthesis of Substituted 2-(5'-Oxo/thioxo-1',3',4'-oxodiazol-2'-yl)indoles and 2-(5'-Oxo/thioxo-1,3,4'-oxodiazol-2'-ylamino)indoles

Indole-2-carboxylates (1a-i) and indole-2-carbamates (12d-i) react with hydrazine hydrate in ethanol to give the corresponding hydrazides (2a-i) and semicarbazides (13d-i).These compounds when heated under reflux with CS2 and KOH give 2-(5'-thioxo-1',3',4'-oxadiazol-2'-yl)indoles (5c,g) and 2-(5'-thioxo-1',3',4'-oxadiazol-2'-ylamino)indoles (16f,g,i).Compounds 2a-i and 13d-i undergo condensation with ethyl chloroformate to give the products 3a-g and 14d,g,h, respectively which on heating under reflux with diphenyl ether give the corresponding 2-(5'-oxo-1',3',4'-oxadiazol-2'-yl)indoles (4a-g) and 2-(5'-oxo-1',3',4'-oxadiazol-2'-ylimino)indoles (15d,g,h).Ethyl 2-phenylindole-3-carbamate (18), obtained from 3-aminoindole (17), has been condensed with hydrazine hydrate to give the semicarbazide (19) which on reation with ethyl chloroformate and heating under reflux with diphenyl ether produces 3-(5'-oxo-1',3',4'-oxadiazol-2'-ylamino)indole (21).