25441-40-1Relevant academic research and scientific papers
Sitagliptin impurity and preparation method and detection method thereof
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, (2021/10/05)
The novel impurity can provide standard reference for quality control of sitagliptin and safety detection of clinical medication, so that safety and reliability of clinical medication are guaranteed. In addition, the preparation method of the impurity compound provided by the invention is simple to operate and mild in reaction conditions, can obtain impurity compounds with high purity and high yield, is used for further researching impurity properties, and provides technical support for the content control of sitagliptin compounds and the safety problems of sitagliptin. The sitagliptin impurity detection method can perform targeted qualitative detection on the impurities, is high in detection precision, and is beneficial to the technical means for detecting impurities in the sitagliptin, so that the quality of the sitagliptin impurity is controlled.
PYRIDINIUM, QUINOLINIUM, ACRIDINIUM, PYRYLIUM, CHROMENYLIUM OR XANTHYLIZUM REACTIVE DESORPTION AND/OR LASER ABLATION IONIZATION MATRICES AND USE THEREOF
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Page/Page column 27, (2019/10/01)
The present disclosure concerns use of compounds of formula I, or salts thereof, as reactive matrices for desorption and laser ablation ionization spectrometry. The disclosure further concerns compounds of formula II, or salts thereof, and use of compound
