254428-47-2

Basic information

• Product Name: (E)-N-(4-bromobenzylidene)-4-methylbenzenesulfonamide
• Synonyms: (E)-N-(4-bromobenzylidene)-4-methylbenzenesulfonamide
• CAS NO: 254428-47-2
• Molecular Weight: 338.225
• Mol File: 254428-47-2.mol

Chemical Properties

• CAS DataBase Reference: (E)-N-(4-bromobenzylidene)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(4-bromobenzylidene)-4-methylbenzenesulfonamide(254428-47-2)
• EPA Substance Registry System: (E)-N-(4-bromobenzylidene)-4-methylbenzenesulfonamide(254428-47-2)

Safety Data

• Hazardous Substances Data: 254428-47-2(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 616241-13-5 (S)-N-(1-(4-bromophenyl)-2-methylene-3-oxobutyl)-4-methylbenzenesulfonamide 
• 159152-11-1 5-(4-bromophenyl)dipyrromethane 
• 439077-75-5 N-[1'-(4''-bromophenyl)-2'-methylene-3'-oxobutyl]-4-methylbenzenesulfonamide 

Relevant articles and documents

Copper-boryl mediated transfer hydrogenation of N-sulfonyl imines using methanol as the hydrogen donor

B2Pin2-assisted copper-catalyzed transfer hydrogenation of aromatic sulfonylimines has been achieved, delivering a variety of aryl/heteroaryl sulfonamides in good to excellent yields under mild reaction conditions and with methanol a

Synthesis and biological evaluation of substituted phenyl azetidine-2-one sulphonyl derivatives as potential antimicrobial and antiviral agents

In the present study, we intend to synthesize a series of novel substituted phenyl azetidine-2-one sulphonyl derivatives. The entire set of derivatives 5 (a-t) were screened for in-vitro antibacterial, and antifungal activity, and among them eleven compou

A General Method for Imine Formation Using B(OCH2CF3)3

Tris(2,2,2-trifluoroethyl)borate [B(OCH2CF3)3] was found to be a mild and general reagent for the formation of a variety of imines by condensation of amides or amines with carbonyl compounds. N-Sulfinyl, N-toluenesulfonyl,

Diastereoselective Johnson-Corey-Chaykovsky trifluoroethylidenation

(2,2,2-Trifluoroethyl)diphenylsulfonium triflate was found to be an efficient ylide reagent for the Johnson-Corey-Chaykovsky reaction to afford trifluoromethyl epoxides, cyclopropanes and aziridines. Interestingly, excellent but different diastereoselectivity was observed for these transformations. Both trifluoromethyl epoxides and cyclopropanes were obtained with trans-selectivity, whereas aziridines were obtained with cis-selectivity.

Triarylmethyl chlorides as novel, efficient, and mild organic catalysts for the synthesis of N-sulfonyl imines under neutral conditions

A highly efficient procedure for the preparation of N-sulfonyl imines via condensation of sulfonamides with aldehydes as well as ketones in the presence of triarylmethyl chlorides as metal-free organo-catalysts at 40 °C is described. The advantages of thi

Small-molecule inhibitors of protein geranylgeranyltransferase type I

Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To further improve the efficacy of the GGTase-I inhibitors (GGTIs), 4288 related compounds bearing core dihydropyrrole/pyrrolidine and tetrahydropyridine/piperidine scaffolds were synthesized on SynPhase lanterns in a split-pool manner through phosphine-catalyzed [3 + 2] and [4 + 2] annulations of resin-bound allenoates. Testing of the 4288 analogues resulted in several GGTIs exhibiting submicromolar IC50 values. Because proteins such as Ras and Rho GTPases are implicated in oncogenesis and metastasis, these GGTIs might ultimately lead to the development of novel antitumor therapeutics. Copyright

Highly diastereoselective and enantioselective direct organocatalytic anti-selective Mannich reactions employing N-tosylimines

Organocatalytic direct anti-selective Mannich reactions of O-TBS-hydroxyacetone with various N-tosylimines derived from aromatic aldehydes in the presence of L-threonine-derived catalyst afforded 1,2-amino alcohols in good yields and with enantioselectivi