254431-91-9

Upstream product

• 10113-39-0 N-formyl-2-iodoaniline 
• 917-92-0 3,3-Dimethylbut-1-yne 
• 116491-51-1 2-(3,3-dimethyl-1-butynyl)aniline 
• 615-43-0 2-iodophenylamine 
• 302351-89-9 o-(1-butynyl-3,3-dimethyl)-N-formanilide 

Relevant academic research and scientific papers

2,3-Difunctionalized Indoles via Radical Acylation or Trifluoromethylation of ortho-Alkynylphenyl Isonitriles

A radical cascade to 2,3-disubstituted indoles proceeding via acylation or trifluoromethylation of ortho-alkynylphenyl isonitriles is presented. In these cascades, two C–C bonds and one C–O bond are formed using an inexpensive oxidant and a catalytic copp

Palladium-Catalyzed Domino Synthesis of 2,3-Difunctionalized Indoles via Migratory Insertion of Isocyanides in Batch and Continuous Flow

We report, herein, a palladium-catalyzed cascade comprising carbopalladation, migratory insertion of isocyanide and triple bond activation followed by a nucleophilic attack (OR?) to construct difunctionalized acyl indoles. The process involves

Cascades to substituted indoles

This paper describes the synthesis of dithioindoles from the free-radical cyclizations of arylisonitriles having pendant alkynes. Also described is the synthesis of substituted indoles and spiro-fused indoles from the coupling of dithioindoles with active hydrogen-containing compounds.

New Access to 2,3-disubstituted Quinolines through Cyclization of o-Alkynylisocyanobenzenes

(Matrix Presented) o-Alkynylisocyanobenzenes underwent nucleophile-induced intramolecular cyclization to give 2,3-disubstituted quinoline derivatives in high yields. In addition to the oxygen and nitrogen nucleophiles such as methanol and diethylamine, the nucleophilic carbon of the enolate of malonate induced the cyclization effectively. Reaction of 1,4-di(trimethylsilylethynyl)-2,3-diisocyanobenzene with methanol afforded 2,9-dimethoxy-1,10-phenanthroline in good yield.