302351-89-9Relevant academic research and scientific papers
2,3-Difunctionalized Indoles via Radical Acylation or Trifluoromethylation of ortho-Alkynylphenyl Isonitriles
Leifert, Dirk,Weidlich, Frauke,Adler, Florin,Daniliuc, Constantin G.,Alasmary, Fatmah A.,Studer, Armido
supporting information, p. 284 - 288 (2021/12/27)
A radical cascade to 2,3-disubstituted indoles proceeding via acylation or trifluoromethylation of ortho-alkynylphenyl isonitriles is presented. In these cascades, two C–C bonds and one C–O bond are formed using an inexpensive oxidant and a catalytic copp
Ruthenium-Catalyzed 1,6-Aromatic Enamide-Silylalkyne Cycloisomerization: Approach to 2,3-Disubstituted Indoles
Takamoto, Kohei,Ohno, Shohei,Hyogo, Norimichi,Fujioka, Hiromichi,Arisawa, Mitsuhiro
, p. 8733 - 8742 (2017/08/23)
Cycloisomerization is an atom economic procedure that converts dienes and enynes into cyclic molecules. To date, cycloisomerization between enamides and silylalkynes has not been explored. We found that N-acyl-N-vinyl-2-silylalkynylaniline derivatives und
Cascades to substituted indoles
Rainier, Jon D.,Kennedy, Abigail R.
, p. 6213 - 6216 (2007/10/03)
This paper describes the synthesis of dithioindoles from the free-radical cyclizations of arylisonitriles having pendant alkynes. Also described is the synthesis of substituted indoles and spiro-fused indoles from the coupling of dithioindoles with active hydrogen-containing compounds.
New Access to 2,3-disubstituted Quinolines through Cyclization of o-Alkynylisocyanobenzenes
Suginome, Michinori,Fukuda, Takeshi,Ito, Yoshihiko
, p. 1977 - 1979 (2008/02/11)
(Matrix Presented) o-Alkynylisocyanobenzenes underwent nucleophile-induced intramolecular cyclization to give 2,3-disubstituted quinoline derivatives in high yields. In addition to the oxygen and nitrogen nucleophiles such as methanol and diethylamine, the nucleophilic carbon of the enolate of malonate induced the cyclization effectively. Reaction of 1,4-di(trimethylsilylethynyl)-2,3-diisocyanobenzene with methanol afforded 2,9-dimethoxy-1,10-phenanthroline in good yield.
