254434-45-2Relevant academic research and scientific papers
Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues
De Jonghe, Steven,Van Overmeire, Ilse,Gunst, Johan,De Bruyn, Andre,Hendrix, Chris,Van Calenbergh, Serge,Busson, Roger,De Keukeleire, Denis,Philippe, Jan,Herdewijn, Piet
, p. 3159 - 3164 (2007/10/03)
Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts.
Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase
De Jonghe, Steven,Van Overmeire, Ilse,Poulton, Samantha,Hendrix, Chris,Busson, Roger,Van Calenbergh, Serge,De Keukeleire, Denis,Spiegel, Sarah,Herdewijn, Piet
, p. 3175 - 3180 (2007/10/03)
Short-chain sphinganine analogues 8, 9, 18, and 19, as well as 3-fluoro-sphingosine analogues 25 and 26 were synthesized. Their potential as sphingosine kinase inhibitors was investigated, in combination with previously synthesized sphingosine and fluorin
