254434-46-3

Upstream product

• 241478-33-1 tert-butyl (4S)-4-<(1R)-1-hydroxy-3-phenyl-2-propynyl>-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 241478-36-4 tert-butyl-(1S,2R)-N-[2-hydroxy-1-(hydroxymethyl)-3-phenylacetylenyl]carbamate 
• 536-74-3 phenylacetylene 
• 90878-19-6 phenethylmagnesium chloride 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 254878-63-2 tert-butyl (4S)-4-[(1RS)-1-hydroxy-3-phenylpropyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 241478-40-0 tert-butyl (1S,2R,3E)-N-[2-hydroxy-1-(hydroxymethyl)-4-phenyl-3-butenyl]carbamate 

Relevant academic research and scientific papers

Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues

Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts.

Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase

Short-chain sphinganine analogues 8, 9, 18, and 19, as well as 3-fluoro-sphingosine analogues 25 and 26 were synthesized. Their potential as sphingosine kinase inhibitors was investigated, in combination with previously synthesized sphingosine and fluorin