254435-95-5 Usage
Uses
Used in Transplant Medicine:
[D-MeAla]3-[EtVal]4-cyclosporin A is used as an immunosuppressive agent for preventing organ rejection in transplant patients. The modification of the cyclosporin A molecule is intended to improve its binding to specific receptors on immune cells, thereby enhancing its ability to suppress their activity and reduce the risk of organ rejection.
Used in Autoimmune Disorder Treatment:
In the treatment of autoimmune disorders, [D-MeAla]3-[EtVal]4-cyclosporin A serves as an immunosuppressive therapy. The modified drug may exhibit enhanced efficacy in managing autoimmune conditions by dampening the overactive immune response, thus alleviating symptoms and preventing disease progression.
Used in Pharmaceutical Research and Development:
[D-MeAla]3-[EtVal]4-cyclosporin A is utilized as a subject of pharmaceutical research and development. The modified cyclosporin A provides insights into the optimization of immunosuppressive drugs, offering a platform for the discovery of novel therapeutic agents with improved safety and efficacy profiles for various clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 254435-95-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,4,4,3 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 254435-95:
(8*2)+(7*5)+(6*4)+(5*4)+(4*3)+(3*5)+(2*9)+(1*5)=145
145 % 10 = 5
So 254435-95-5 is a valid CAS Registry Number.
254435-95-5Relevant academic research and scientific papers
NON-IMMUNOSUPPRESSIVE CYCLOSPORIN FOR TREATMENT OF ULLRICH CONGENITAL MUSCULAR DYSTROPHY
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Page/Page column 21-22, (2008/12/07)
The present invention relates to the use of a nonimmunosuppressive cyclosporin A derivative for reducing mitochondrial dysfunction and the rate of apoptosis of muscle cells of patients diagnosed with Ullrich congenital muscular dystrophy or Bethlem myopat
