254435-95-5 Usage
General Description
[D-MeAla]3-[EtVal]4-cyclosporin A is a modified version of the immunosuppressive drug cyclosporin A, which is commonly used to prevent organ rejection in transplant patients. This modification involves the substitution of three D-methylalanines and four ethylvalines in the cyclosporin A molecule. These changes are intended to enhance the drug's pharmacological properties, such as its ability to bind to specific receptors on immune cells, thus suppressing their activity. The modified cyclosporin A may have improved efficacy and reduced side effects compared to the original drug, making it a potentially valuable option for transplant patients and individuals with autoimmune disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 254435-95-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,4,4,3 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 254435-95:
(8*2)+(7*5)+(6*4)+(5*4)+(4*3)+(3*5)+(2*9)+(1*5)=145
145 % 10 = 5
So 254435-95-5 is a valid CAS Registry Number.
254435-95-5Relevant articles and documents
NON-IMMUNOSUPPRESSIVE CYCLOSPORIN FOR TREATMENT OF ULLRICH CONGENITAL MUSCULAR DYSTROPHY
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Page/Page column 21-22, (2008/12/07)
The present invention relates to the use of a nonimmunosuppressive cyclosporin A derivative for reducing mitochondrial dysfunction and the rate of apoptosis of muscle cells of patients diagnosed with Ullrich congenital muscular dystrophy or Bethlem myopat
