25457-99-2

Usage

Structure

2-((E)-(3-bromophenyl)methylideneamino)-2-methylpropan-1-ol
The compound has a structure that includes a 3-bromophenyl group, a methylidene amino group, a methyl group, and a hydroxyl group.

Functional groups

Bromine atom, Phenyl group, Amino group, Methyl group, Hydroxyl group
The compound contains various functional groups, such as a bromine atom, a phenyl group, an amino group, a methyl group, and a hydroxyl group, which contribute to its chemical properties and reactivity.

Double bond

Between the phenyl group and the methylidene amino group

Reagent and intermediate

Used in organic synthesis
2-[(E)-(3-bromophenyl)methylidene]amino-2-methylpropan-1-ol is utilized as a reagent and intermediate in various organic synthesis processes.

Application

Depends on specific use in research and industrial processes
The exact properties and applications of this chemical compound are determined by its particular use in research and industrial processes.

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Relevant academic research and scientific papers

Chemical Proteomics Approach for Profiling the NAD Interactome

Nicotinamide adenine dinucleotide (NAD+) is a multifunctional molecule. Beyond redox metabolism, NAD+ has an equally important function as a substrate for post-translational modification enzymes, the largest family being the poly-ADP-ribose polymerases (PARPs, 17 family members in humans). The recent surprising discoveries of noncanonical NAD (NAD+/NADH)-binding proteins suggests that the NAD interactome is likely larger than previously thought; yet, broadly useful chemical tools for profiling and discovering NAD-binding proteins do not exist. Here, we describe the design, synthesis, and validation of clickable, photoaffinity labeling (PAL) probes, 2- and 6-ad-BAD, for interrogating the NAD interactome. We found that 2-ad-BAD efficiently labels PARPs in a UV-dependent manner. Chemical proteomics experiments with 2- and 6-ad-BAD identified known and unknown NAD+/NADH-binding proteins. Together, our study shows the utility of 2- and 6-ad-BAD as clickable PAL NAD probes.

HYDROXY SCHIFF BASE-OXAZOLIDINE TAUTOMERISM: APPARENT BREAKDOWN OF BALDWIN'S RULES

The tautomerism between hydroxy Schiff bases, X=C6H4CR=NCMe2CH2OH (R=H, Me, C6H5; X is a range of substituents) and X=C6H4CR=NC6H4(o-CH2OH), and the corresponding ring closed systems, oxazolidines and dihydrobenzoxazines, has been investigated.In all case