2546-44-3Relevant academic research and scientific papers
MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS
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Paragraph 0390-0392, (2021/04/17)
Provided herein, inter alia, are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
Direct Nucleophilic Difluoromethylation of Carbonyl Compounds
Deng, Zuyong,Lin, Jin-Hong,Cai, Ji,Xiao, Ji-Chang
supporting information, p. 3206 - 3209 (2016/07/14)
Phosphonium salt ([Ph3P+CF2H] Br-, DFPB) was found to be an efficient nucleophilic difluoromethylation reagent. Although DFPB is known as a phosphonium ylide precursor, its reaction with carbonyl compounds under traditional Wittig reaction conditions did not give the expected Wittig difluoroolefinated products, but afforded the nucleophilic difluoromethylation products, α-CF2H alcohols. Mechanistic investigation reveals that the unexpected transformation proceeded via the direct transfer of the CF2H group, which resulted from the high P-O affinity.
Difluromethylphosphonium salt, and preparation method and application thereof
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Paragraph 0159; 0160; 0161; 0162, (2017/08/02)
The invention discloses difluromethylphosphonium salt, and a preparation method and application thereof. A synthetic method of the difluromethylphosphonium salt disclosed by the invention comprises the following steps of in a solvent, carrying out a react
Organocatalytic direct difluoromethylation of aldehydes and ketones with TMSCF2H
Du, Guang-Fen,Wang, Ying,Gu, Cheng-Zhi,Dai, Bin,He, Lin
, p. 35421 - 35424 (2015/05/05)
An organic Lewis base promoted direct difluoromethylation reaction of carbonyl compounds with Me3SiCF2H has been studied. The Schwesinger's superbase can efficiently activate the Si-CF2H bond and initiate the difluoromethy
