50561-95-0 Usage
Uses
Used in Pharmaceutical Industry:
1-(2,2-difluoroethyl)-4-fluorobenzene is used as a building block for the synthesis of various organic compounds, playing a crucial role in the development of new pharmaceutical products. Its unique structure allows for the creation of molecules with specific therapeutic properties.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 1-(2,2-difluoroethyl)-4-fluorobenzene serves as a key component in the synthesis of organic compounds utilized in the development of pesticides, herbicides, and other agricultural chemicals, contributing to enhanced crop protection and yield.
Used as a Reagent in Organic Synthesis:
1-(2,2-difluoroethyl)-4-fluorobenzene is also employed as a reagent in organic synthesis, facilitating various chemical reactions and contributing to the formation of desired products with specific functional groups.
Used as a Solvent in Chemical Reactions:
Furthermore, 1-(2,2-difluoroethyl)-4-fluorobenzene is utilized as a solvent in chemical reactions, providing a suitable medium for the reactants to interact, thus influencing the reaction rate and product formation.
Safety Precautions:
It is important to handle 1-(2,2-difluoroethyl)-4-fluorobenzene with care, as it is flammable and may release toxic fumes when heated. Additionally, it may cause skin and eye irritation upon contact, necessitating proper safety measures during its use in laboratories and industrial settings.
Check Digit Verification of cas no
The CAS Registry Mumber 50561-95-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,5,6 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 50561-95:
(7*5)+(6*0)+(5*5)+(4*6)+(3*1)+(2*9)+(1*5)=110
110 % 10 = 0
So 50561-95-0 is a valid CAS Registry Number.
50561-95-0Relevant academic research and scientific papers
Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates
Doobary, Sayad,Sedikides, Alexi T.,Caldora, Henry P.,Poole, Darren L.,Lennox, Alastair J. J.
supporting information, p. 1155 - 1160 (2019/12/11)
Fluorinated alkyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochemical generation of a hypervalent iodine mediator using an “ex-cell” approach, which avoids oxidative substrate decomposition. The more sustainable conditions give good to excellent yields in up to decagram scales.
Hypervalent Iodine-Mediated Fluorination of Styrene Derivatives: Stoichiometric and Catalytic Transformation to 2,2-Difluoroethylarenes
Kitamura, Tsugio,Muta, Kensuke,Oyamada, Juzo
, p. 10431 - 10436 (2015/11/18)
Fluorination of styrene derivatives with a reagent system composed of μ-oxo-bis[trifluoroacetato(phenyl)iodine] and a pyridine·HF complex gave the corresponding (2,2-difluoroethyl)arenes in good yields. Similarly, the reagent of PhI(OCOCF3)2 and the pyridine·HF complex acted as a fluorinating agent for styrene derivatives. The fluorination of styrene derivatives with the pyridine·HF complex underwent under catalytic conditions using 4-iodotoluene as a catalyst and m-CPBA as a terminal oxidant.
