25462-38-8

Upstream product

• 26395-09-5 diethyl 2-(3-phenylpropyl)malonate 
• 104-53-0 3-phenyl-propionaldehyde 
• 16501-24-9 S,S'-diethyl dithiomalonate 

Downstream Products

• 1266334-63-7 (R)-2-hydroxymethyl-5-phenylpentyl acetate 
• 1266334-67-1 2-acetoxymethyl-5-phenylpentyl acetate 
• 1266334-64-8 (R)-2-hydroxymethyl-5-phenylpentyl propanoate 
• 1266334-68-2 5-phenyl-2-propanoyloxymethylpentyl propanoate 
• 1266334-65-9 (R)-2-hydroxymethyl-5-phenylpentyl butanoate 
• 1266334-69-3 2-butanoyloxymethyl-5-phenylpentyl butanoate 

Relevant academic research and scientific papers

Lipase-mediated preparation of optically active isomers of Rosaphen

The optically active isomers of Rosaphen (RS)-1 were synthesized from the chiral intermediate prepared by lipase-catalyzed desymmetrization of prochiral diol. The results of an olfactory evaluation of the prepared isomers are reported.

Thiol esters in organic synthesis XVII. S,S'-diethyl dithiomalonate as masked ethanol carbanion and 1,3-diol equivalent in the Knoevenagel condensation

S,S'-Diethyl dithiomalonate (1) has been shown to be a useful reagent in the Knoevenagel condensation with aldehydes, using DABCO as the base. The resultant products can be reduced either to 1,3-diols by use of sodium borohydride or to ethanol derivatives using Raney Nickel.

Certain 2-substituted 1,3-propylidenediphosphonate derivatives, pharmaceutical compositions containing them and their use as antihypertensive agents

2-Substituted-1,3-propylidenediphosphonates of formula (I), where A, R1 and R2 are defined in claim 1, are therapeutically active compounds, namely for the treatment of cardiovascular diseases. They can be prepared by reacting phosphonating agents with 1,3- dibromopropanes or ditosylates of 1,3-propanediols substituted in position 2. STR1 .