25467-67-8Relevant academic research and scientific papers
Synthesis of thioether derivatives of quinazoline-4-one-2-thione and evaluation of their antiplatelet aggregation activity
Eskandariyan, Zahra,Esfahani Zadeh, Marjan,Haj Mohammad Ebrahim Tehrani, Kamaleddin,Mashayekhi, Vida,Kobarfard, Farzad
, p. 332 - 339 (2014)
A series of 2-(arylmethylthio)-3-phenylquinazolin-4-one derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma. Among the tested thioethers, derivative 2, 3, 5 and 16 were the most potent compounds with satisfactory IC50 for inhibition of platelet aggregation induced by ADP. Analysis of global physicochemical parameters shows some correlations between activities and molecular volume and also surface area of the studied derivatives.
