25472-99-5Relevant academic research and scientific papers
Synthesis, in-vitro microbial and cytotoxic studies of new benzimidazole derivatives
Harisha, Reddy S.,Hosamani, Kallappa M.,Keri, Rangappa S.
experimental part, p. 412 - 419 (2009/12/01)
Several new classes of benzimidazole derivatives were synthesized and evaluated for in-vitro antimicrobial and cytotoxic activities. The results showed that all synthesized compounds exhibited moderate antimicrobial activity, and compounds 2, 4, and 13 displayed cytotoxic activity (as LD50) at the concentration 1 × 10-3 M against Artemia salina.
Synthesis of some 2-(5-substituted 1,3,4-oxadiazol-2-yl)-, 2-(5-substituted 1,3,4-thiadiazol-2-yl)- and 2-(3-mercapto-4-substituted-4H-1,2,4-triazol-5-yl)benzimidazoles as potential antiinflammatory agents
Sawhney, S N,Gupta, Asha
, p. 407 - 412 (2007/10/02)
2-(5-Alkyl/aryl-1,3,4-oxadiazol-2-yl)- (I), 2-(5-alkyl/aryl-1,3,4-thiadiazol-2-yl)- (II), 2-(5-substituted amino-1,3,4-oxadiazol-2-yl)- (III), 2-(5-substituted amino-1,3,4-thiadiazol-2-yl)- (IV) and 2-(3-mercapto-4-alkyl/aryl-4H-1,2,4-triazol-5-yl)-(V) benzimidazoles have been synthesized as potential antiinflammatory agents.None of the compounds shows any significant antiiflammatory activity in carrageenin-induced rat paw edema test.
