5436-00-0

Usage

Chemical structure

A hydrazide derivative of benzimidazole carboxylic acid

Applications

a. Building block for the synthesis of pharmaceuticals and agrochemicals
b. Potential use in medicinal chemistry as a ligand for metal ion complexes
c. Exhibits diverse biological activities (anti-tumor, anti-inflammatory, and anti-microbial properties)
d. Potential use as a corrosion inhibitor in industrial applications

Fields of application

a. Pharmaceuticals
b. Agrochemicals
c. Materials science

InChI:InChI=1/C8H8N4O/c9-12-8(13)7-10-5-3-1-2-4-6(5)11-7/h1-4H,9H2,(H,10,11)(H,12,13)

Upstream product

• 2849-93-6 2-benzimidazolecarboxylic acid 

Downstream Products

• 26286-46-4 2-(2-Benzimidazolyl)-1,3,4-oxadiazol 
• 107997-41-1 1H-Benzoimidazole-2-carboxylic acid cyclohexylidene-hydrazide 
• 107997-35-3 1H-Benzoimidazole-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 2849-93-6 2-benzimidazolecarboxylic acid 
• 1865-09-4 ethyl 1H-benzimidazole-2-carboxylate 
• 107997-51-3 1H-Benzoimidazole-2-carboxylic acid (3,5-dimethyl-phenyl)-amide 
• 107997-50-2 1H-Benzoimidazole-2-carboxylic acid (3,5-dichloro-phenyl)-amide 
• 25472-99-5 C₁₅H₁₃N₅OS 

Relevant academic research and scientific papers

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

Chikungunya virus is a re-emerging arbovirus transmitted to humans by Aedes mosquitoes, responsible for an acute febrile illness associated with painful and debilitating arthralgia, which can persist for several months or become chronic. Over the past few years, infection with this virus has spread worldwide with a previously unknown virulence. No specific antiviral treatments nor vaccines are currently available against this important pathogen. Starting from the structure of a class of selective anti-CHIKV agents previously identified in our research group, different modifications to this scaffold were rationally designed, and 69 novel small-molecule derivatives were synthesised and evaluated for their inhibition of Chikungunya virus replication in Vero cells. Further structure-activity relationships associated with this class of antiviral agents were elucidated for the original scaffolds, and novel antiviral compounds with EC50 values in the low micromolar range were identified. This work provides the foundation for further investigation of these new structures as antivirals against Chikungunya virus.

Synthesis and characterization of nitrogen heterocyclic derivatives containing sulfur-ether and schiff base

A series of new nitrogen heterocyclic compounds containing sulfur-ether (8a-8f) and Schiff-base (9a-9q) functionalities were synthesized by the reaction of the pharmaceutical lead compound containing both benzimidazole and 1,2,4-triazole rings. The compounds were characterized by 1H NMR, 13C NMR, FT-IR, HR-MS, and ESI-MS.