254744-54-2

Upstream product

• 254744-53-1 2-[(2'-bromo-5'-formyl)phenyl]-1,3-dioxolane 
• 160313-50-8 2-[(2'-bromo-5'-cyano)phenyl]-1,3-dioxolane 
• 160313-48-4 2-[(2'-bromo-5'-hydroxymethyl)phenyl]-1,3-dioxolane 

Downstream Products

• 467423-51-4 4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid 
• 254744-58-6 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide 
• 254737-86-5 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 
• 254744-56-4 4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene 
• 254744-55-3 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene 

Relevant academic research and scientific papers

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists

The ETA receptor antagonist (2) (N-(3,4-dimethyl-5-isoxazolyl)-4′-(2-oxazolyl)-[1,1′-biphenyl] -2-sulfonamide, BMS-193884) shares the same biphenyl core as a large number of AT1 receptor antagonists, including irbesartan (3). Thus, i