254744-56-4

Upstream product

• 138402-05-8 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one 
• 160313-50-8 2-[(2'-bromo-5'-cyano)phenyl]-1,3-dioxolane 
• 160313-48-4 2-[(2'-bromo-5'-hydroxymethyl)phenyl]-1,3-dioxolane 
• 254744-53-1 2-[(2'-bromo-5'-formyl)phenyl]-1,3-dioxolane 
• 254744-55-3 2-(1,3-Dioxolan-2-yl)-4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]bromobenzene 
• 254744-54-2 2-[(2'-bromo-5'-bromomethyl)phenyl]-1,3-dioxolane 

Downstream Products

• 254744-58-6 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide 
• 467423-51-4 4-{[4-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-biphenyl-2-ylmethyl]-amino}-2,2-dimethyl-butyric acid 
• 254737-86-5 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 

Relevant academic research and scientific papers

Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists

Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutica

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists

The ETA receptor antagonist (2) (N-(3,4-dimethyl-5-isoxazolyl)-4′-(2-oxazolyl)-[1,1′-biphenyl] -2-sulfonamide, BMS-193884) shares the same biphenyl core as a large number of AT1 receptor antagonists, including irbesartan (3). Thus, i

Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists

Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutica