254745-01-2Relevant academic research and scientific papers
Aza-Henry reactions on C-Alkyl substituted aldimines
Pelagalli, Alessia,Pellacani, Lucio,Scandozza, Elia,Fioravanti, Stefania
, (2016)
The reactivity of C-CH3 substituted N-protected aldimines in aza-Henry addition reactions was compared with that of the analogous trifluoromethylated compounds. C-Alkyl aldimines easily reacted with nitro alkanes under solvent-free conditions and in the absence of catalyst, despite being worse electrophiles than C-CF3 aldimines, they gave the aza-Henry addition only when ZrCl4 was added. The presence of a bulky group on the imine carbon deeply influenced the reactivity.
Asymmetric addition of alkyllithium to chiral imines: α-Naphthylethyl group as a chiral auxiliary
Yamada, Hideki,Kawate, Tomohiko,Nishida, Atsushi,Nakagawa, Masako
, p. 8821 - 8828 (2007/10/03)
The diastereoselective nucleophilic addition of alkyllithium to N- alkylidene-α-naphthylethylamine was carried out. In the presence of Lewis acids or Lewis bases, organolithiums reacted smoothly with imines to give the corresponding amines in high stereoselectivity (up to 100% de). Furthermore, the resulting optically active amines were found to be useful for asymmetric reactions as chiral ligands.
