254750-63-5

Upstream product

• 2018-66-8 Z-Leu-OH 
• 161401-79-2 3-amino-4-hydroxy-5-fluoropentanoic acid,tert-butyl ester 
• 161401-79-2 (3RS,4RS)-3-amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester 
• 3397-35-1 Z-L-leucine hydroxysuccinimide ester 

Downstream Products

• 254750-65-7 (3RS,4RS)-3-(leucinyl)amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester, p-toluenesulfonate salt 
• 254750-65-7 (3RS,4RS)-3-(leucinyl)amino-5-fluoro-4-hydroxypentanoic acid, tert-butyl ester, p-toluenesulfonate salt 

Relevant academic research and scientific papers

Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid

This article describes the synthesis and biological evaluation of a series of dipeptidyl aspartyl fluoromethylketones as caspase-3 inhibitors. Structure-activity relationship (SAR) studies showed that for caspase-3 inhibition, Val is the best P2 amino acid. The SAR studies also showed that the Asp free carboxylic acid in P1 is important for caspase inhibiting activities, as well as for selectivity over other proteases.

(Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases

This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of pa