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254751-11-6

N-(2-phenoxy-phenyl)-oxalamic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 254751-11-6 Structure

  • Basic information

    1. Product Name: N-(2-phenoxy-phenyl)-oxalamic acid
    2. Synonyms: N-(2-phenoxy-phenyl)-oxalamic acid
    3. CAS NO:254751-11-6
    4. Molecular Formula:
    5. Molecular Weight: 257.246
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 254751-11-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(2-phenoxy-phenyl)-oxalamic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(2-phenoxy-phenyl)-oxalamic acid(254751-11-6)
    11. EPA Substance Registry System: N-(2-phenoxy-phenyl)-oxalamic acid(254751-11-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 254751-11-6(Hazardous Substances Data)

254751-11-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 254751-11-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,4,7,5 and 1 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 254751-11:
(8*2)+(7*5)+(6*4)+(5*7)+(4*5)+(3*1)+(2*1)+(1*1)=136
136 % 10 = 6
So 254751-11-6 is a valid CAS Registry Number.

254751-11-6Upstream product

254751-11-6Downstream Products

254751-11-6Relevant articles and documents

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

Linton, Steven D.,Aja, Teresa,Allegrini, Peter R.,Deckwerth, Thomas L.,Diaz, Jose-Luis,Hengerer, Bastian,Herrmann, Julia,Jahangiri, Kathy G.,Kallen, Joerg,Karanewsky, Donald S.,Meduna, Steven P.,Nalley, Kip,Robinson, Edward D.,Roggo, Silvio,Rovelli, Giorgio,Sauter, Andre,Sayers, Robert O.,Schmitz, Albert,Smidt, Robert,Ternansky, Robert J.,Tomaselli, Kevin J.,Ullman, Brett R.,Wiessner, Christoph,Wu, Joe C.

, p. 2685 - 2691 (2004)

Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.

First-in-class pan caspase inhibitor developed for the treatment of liver disease

Linton, Steven D.,Aja, Teresa,Armstrong, Robert A.,Bai, Xu,Chen, Long-Shiuh,Chen, Ning,Ching, Brett,Contreras, Patricia,Diaz, Jose-Luis,Fisher, Craig D.,Fritz, Lawrence C.,Gladstone, Patricia,Groessl, Todd,Gu, Xin,Herrmann, Julia,Hirakawa, Brad P.,Hoglen, Niel C.,Jahangiri, Kathy G.,Kalish, Vincent J.,Karanewsky, Donald S.,Kodandapani, Lalitha,Krebs, Joseph,McQuiston, Jeff,Meduna, Steven P.,Nalley, Kip,Robinson, Edward D.,Sayers, Robert O.,Sebring, Kristen,Spada, Alfred P.,Ternansky, Robert J.,Tomaselli, Kevin J.,Ullman, Brett R.,Valentino, Karen L.,Weeks, Suzanne,Winn, David,Wu, Joe C.,Yeo, Pauline,Zhang, Cheng-Zhi

, p. 6779 - 6782 (2007/10/03)

A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in vitro data, inhibitors were selected for study in a murine model of α-Fas-induced liver injury. IDN-6556 (1) was further profiled in additional in vivo models and pharmacokinetic studies. This first-in-class caspase inhibitor is now the subject of two Phase II clinical trials, evaluating its safety and efficacy for use in liver disease.

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