254893-78-2

Upstream product

• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 137664-76-7 (S)-3-[1,3]Dithian-2-yl-3-methyl-butane-1,2-diol 
• 137664-75-6 2-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-2-methyl-propionaldehyde 
• 137664-71-2 2-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-2-methyl-propan-1-ol 

Downstream Products

• 218785-39-8 2,2-dimethyl-propionic acid 7-[7-(2-benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-2,4-dimethyl-heptyl ester 
• 254894-52-5 2,2-Dimethyl-propionic acid (2S,3S,4R,5R,7R)-7-[(2S,3S,5S,7R,8S,9S)-7-(2-benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-3,5-dihydroxy-7-methoxy-2,4-dimethyl-heptyl ester 
• 218785-33-2 (1R,4S)-1-[(2S,3S,5S,7R,8S,9S)-7-(2-Benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-1-methoxy-4-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-pentan-3-one 
• 254894-24-1 (2S,3S,5S,7R,8R,9S)-7-(2-Benzyloxy-ethyl)-2-((R)-2-[1,3]dithian-2-yl-1-methoxy-ethyl)-3,9-bis-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]decane 
• 254894-22-9 (2R,3S,5S,7R,8R,9S)-7-(2-Benzyloxy-ethyl)-3,9-bis-(4-methoxy-benzyloxy)-4,4,8-trimethyl-2-(R)-oxiranyl-1,6-dioxa-spiro[4.5]decane 
• 254893-88-4 (2S,3S,4R)-6-Benzyloxy-1-{2-[(2S,3S)-3-hydroxy-2-(4-methoxy-benzyloxy)-1,1-dimethyl-pent-4-enyl]-[1,3]dithian-2-yl}-3-methyl-hexane-2,4-diol 
• 218785-10-5 (1R,3R,4R)-1-[(2S,3S,5S,7R,8S,9S)-7-(2-Benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-1-methoxy-4-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-pentan-3-ol 
• 218785-18-3 C₆₃H₁₂₅O₁₃PSi₅ 
• 218785-37-6 C₆₁H₁₀₈O₁₁Si₃ 
• 218785-31-0 {(2S,3S,5S,7R,8S,9S)-7-(2-Benzyloxy-ethyl)-3-(4-methoxy-benzyloxy)-2-[(1R,4R)-1-methoxy-3-methylene-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-pentyl]-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-9-yloxy}-tert-butyl-dimethyl-silane 
• 218785-08-1 (1R,4R)-1-[(2S,3S,5S,7R,8S,9S)-7-(2-Benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-3-methylene-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-pentan-1-ol 
• 218785-35-4 (2S,3S,4R,5R,7R)-7-[(2S,3S,5S,7R,8S,9S)-7-(2-Benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-7-methoxy-2,4-dimethyl-heptane-1,3,5-triol 
• 218785-05-8 [(2R,3S,5S,7R,8S,9S)-7-(2-Benzyloxy-ethyl)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-2-(R)-oxiranyl-1,6-dioxa-spiro[4.5]dec-9-yloxy]-tert-butyl-dimethyl-silane 
• 162991-28-8 (2R,3S,5S,7R,8R,9S)-7-(2-Benzyloxy-ethyl)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-2-(R)-oxiranyl-1,6-dioxa-spiro[4.5]decan-9-ol 

Relevant academic research and scientific papers

Total synthesis of (+)-calyculin A and (-)-calyculin B: Asymmetric synthesis of the C(9-25) spiroketal dipropionate subunit

An asymmetric synthesis of the stereochemically fully endowed C(9-25) spiroketal fragment (+)-BC of the calyculins (1-8) is described. Highlights of the synthesis include: a highly diastereoselective IBr-induced iodocarbonate cyclization to introduce the

CALYCULIN SYNTHETIC STUDIES. STEREOSELECTIVE CONSTRUCTION OF THE C(14)-C(25) SPIROKETAL SUBUNIT

A convergent, stereocontrolled synthesis of the spiroketal fragment of calyculins A-H has been achieved.Key transformations include the novel iodine monobromide-induced iodocarbonate cyclization of (+)-19, efficient coupling of epoxide (+)-14 with the ste