254964-14-2Relevant academic research and scientific papers
Application of an organozinc reagent derived from (S)-pyroglutamic acid: A formal synthesis of epibatidine
Karstens, Willem F. J.,Moolenaar, Marinus J.,Rutjes, Floris P. J. T.,Grabowska, Urszula,Speckamp, W. Nico,Hiemstra, Henk
, p. 8629 - 8632 (1999)
A formal total synthesis of natural (-)-epibatidine has been developed. Key steps in the synthesis are a copper(I)-mediated coupling of an (S)-pyroglutamic acid-derived organozinc reagent with 1-iodo-3-trimethylsilyl-1-propyne and an N-acyl- or N-sulfonyl
