
Tetrahedron Letters p. 8629 - 8632 (1999)
Update date:2022-08-05
Topics:
Karstens, Willem F. J.
Moolenaar, Marinus J.
Rutjes, Floris P. J. T.
Grabowska, Urszula
Speckamp, W. Nico
Hiemstra, Henk
A formal total synthesis of natural (-)-epibatidine has been developed. Key steps in the synthesis are a copper(I)-mediated coupling of an (S)-pyroglutamic acid-derived organozinc reagent with 1-iodo-3-trimethylsilyl-1-propyne and an N-acyl- or N-sulfonyl
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