2550-89-2

Upstream product

• 153582-27-5 3,3-(ethylenedioxy)-5α-cholest-7-en-6-one 
• 14858-06-1 3β-hydroxy-5α-cholest-7-en-6-one 
• 2259-91-8 5α-cholest-7-ene-3β,6α-diol 
• 1059-86-5 7-Dehydrocholesteryl acetate 
• 16826-35-0 cholesta-4,7-dien-3-one 
• 103326-74-5 3,3-(ethylenedioxy)-cholesta-5,7-diene 
• 136985-72-3 3,3-(ethylenedioxy)-5α-cholest-7-en-6α-ol 
• 434-16-2 7-dehydrocholesterol 
• 1262677-33-7 (S)-3-Triethylsiloxy-5,7-cholestadiene 
• 1262677-34-8 (3S, 5S, 6S)-3-Triethylsiloxy-7-cholesten-6-ol 

Downstream Products

• 1262676-25-4 (3S,5S)-3-Hydroxy-7-oxa-8-cholesten-6-one 
• 1262677-25-7 (3R,5S)-3-hydroxy-7-oxa-8-cholesten-6-one 
• 1262677-35-9 (1S,2R)-2-methyl-2-[(1R,3aR,5R,7aR)-7a-methyl-1-[(R)-6-methylheptan-2-yl]-4-oxooctahydro-1H-inden-5-yl]-5-oxocyclohexanecarboxylic acid 

Relevant academic research and scientific papers

3β-Hydroxy-5β-cholest-7-en-6-one as an Intermediate of 20-Hydroxyecdysone Biosynthesis in a Hairy Root Culture of Ajuga reptans var. atropurpurea

-, - and -Cholesterols and - and -3β-hydroxy-5β-cholest-7-en-6-ones were converted with a hairy root culture of Ajuga reptans var. atropurpurea into 20-hydroxyecdysone, in which the deuterium atoms retained their original positions, thus strongly suggesting that 3β-hydroxy-5β-cholest-7-en-6-one is an obligatory intermediate in the biosynthesis of ecdysteroids in the plant.

STEROL DERIVATIVE

The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.

Synthesis of potential inhibitors of the biosynthesis of ecdysone, the moulting hormone of insects

We have synthesized new potential acetylenic inhibitors of the last step in the biosynthesis of ecdysone, the moulting hormone of insects.The key step in our synthesis is the introduction of the A/B cis ring junction (5β-H configuration) by regio- and stereoselective hydroboration of the Δ5 double bond (B-ring) of 7-dehydrocholesterol. - Keywords: ecdysteroid / ecdysteroid inhibitors / hydroboration / acetylenic derivatives