255050-44-3

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-hydroxy-4-[4-methoxy-2-(methylthio)phenyl]-, phenylmethyl ester
• CAS NO: 255050-44-3
• Molecular Formula: C21H25NO4S
• Molecular Weight: 387.5
• Mol File: 255050-44-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-hydroxy-4-[4-methoxy-2-(methylthio)phenyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-hydroxy-4-[4-methoxy-2-(methylthio)phenyl]-, phenylmethyl ester(255050-44-3)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-hydroxy-4-[4-methoxy-2-(methylthio)phenyl]-, phenylmethyl ester(255050-44-3)

Safety Data

• Hazardous Substances Data: 255050-44-3(Hazardous Substances Data)

Upstream product

• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 72856-79-2 1-bromo-4-methoxy-2-(methylsulfanyl)benzene 
• 150-19-6 O-methylresorcine 
• 63604-94-4 2-bromo-5-methoxyphenol 
• 13993-51-6 2-bromo-5-methoxybenzenethiol 
• 115768-56-4 2-bromo-5-methoxy-(N,N-dimethylthiocarbamoyloxy)phenol 
• 115768-57-5 4-bromo-3-(N,N-dimethylthiocarbamoylthio)methoxybenzene 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 

Downstream Products

• 255050-47-6 4-(4-methoxy-2-(S)-methylsulfinylphenyl)piperidine 
• 255050-45-4 4-(4-methoxy-2-methylthiophenyl)-N-Cbz-piperidine 
• 255050-46-5 4-(4-methoxy-2-(S)-methylsulfinylphenyl)-N-Cbz-piperidine 
• 255051-29-7 4-[4-hydroxy-2-(R,S)-methylsulfinylphenyl]piperidine 
• 255051-27-5 4-(4-methoxy-2-methylthiophenyl)piperidine 

Relevant articles and documents

A New Approach to Rapid Parallel Development of Four Neurokinin Antagonists. Part 4. Synthesis of ZD2249 Methoxy Sulfoxide

The manufacture of ZD2249 methoxy sulfoxide (1) using a new project approach is described. Research department processes were scaled up to 100 L if process safety and robustness were not compromised; other factors were treated according to the new approach. Using this strategy, we were able to manufacture a key intermediate on sufficient scale to support delivery of 1 kg quantities of bulk drug within 6 months of the start of lab work.

N-SUBSTITUTED NAPHTHALENE CARBOXAMIDES AS NEUROKININ-RECEPTOR ANTAGONISTS

A compound of formula I wherein: R is alkyl; R1 is optionally substituted phenyl 2-oxo-tetrahydro-1(2H)-pyrimidinyl, or 2-oxo-1-piperidinyl; R2 is hydrogen, alkoxy, alkanoyloxy, alkoxycarbonyl, alkanoylamino, acyl, alkyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl where the alkyl groups are the same or different, hydroxy, thioacyl, thiocarbamoyl, N-alkylthiocarbamoyl, or N,N-dialkylthiocarbamoyl where the alkyl groups are the same or different. X1 and X2 are independently hydrogen or halo, provided that at least one of X1 or X2 is halo; and R3, R4, R5 and R6 are independently hydrogen, cyano, nitro, trifluoromethoxy, trifluoromethyl, or alkylsulfonyl are antagonists of at least one tachykinin receptor and are useful in the treatment of depression, anxiety, asthma, pain, inflammation, urinary incontinence and other disease conditions. Process for their preparation are described, as are compositions containing them and their use.