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Usage

Physical state

Colorless to light yellow liquid This describes the appearance of the compound, which is a liquid with a color ranging from colorless to light yellow.

Primary uses

Synthesis of pharmaceuticals and agrochemicals The compound is mainly used in the production of medications and chemicals for agricultural purposes.

Intermediate in organic synthesis

Production of biologically active compounds 1-Bromo-4-methoxy-2-methylsulfanyl-benzene serves as a starting material or intermediate in the synthesis of other organic compounds, particularly those with biological activity.

Potent aromatic and pleasant odor

Commonly used as fragrance and flavoring agent The compound has a strong and pleasant smell, making it suitable for use in various consumer products as a fragrance or flavoring agent.

Hazardous if not properly managed

Irritation and other health hazards If not handled correctly, 1-Bromo-4-methoxy-2-methylsulfanyl-benzene can cause irritation and other health issues, emphasizing the importance of proper handling and management of the chemical.

Upstream product

• 150-19-6 O-methylresorcine 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 
• 74-88-4 methyl iodide 
• 17332-11-5 2-bromo-4-methoxyphenol 
• 115768-57-5 4-bromo-3-(N,N-dimethylthiocarbamoylthio)methoxybenzene 
• 10365-98-7 3-methoxyphenylboronic acid 
• 4973-66-4 methyl thiotosylate 
• 89694-44-0 (2-bromo-5-methoxyphenyl)boronic acid 
• 115768-56-4 2-bromo-5-methoxy-(N,N-dimethylthiocarbamoyloxy)phenol 
• 63604-94-4 2-bromo-5-methoxyphenol 
• 13993-51-6 2-bromo-5-methoxybenzenethiol 

Downstream Products

• 255051-27-5 4-(4-methoxy-2-methylthiophenyl)piperidine 
• 255051-29-7 4-[4-hydroxy-2-(R,S)-methylsulfinylphenyl]piperidine 
• 255051-30-0 1-benzyloxycarbonyl-4-(4-hydroxy-2-methylthiophenyl)piperidine 
• 255051-31-1 1-benzyloxycarbonyl-4-(4-hydroxy-2-(R,S)-methylsulfinylphenyl)piperidine 
• 255050-47-6 4-(4-methoxy-2-(S)-methylsulfinylphenyl)piperidine 
• 255050-45-4 4-(4-methoxy-2-methylthiophenyl)-N-Cbz-piperidine 
• 255050-46-5 4-(4-methoxy-2-(S)-methylsulfinylphenyl)-N-Cbz-piperidine 

Relevant academic research and scientific papers

Synthesis of Benzothieno[60]fullerenes through Fullerenyl Cation Intermediates

Benzothieno[60]fullerenes were synthesized using fullerenyl cations as key intermediates. The reaction proceeded through a nucleophilic attack of the sulfur atom as a weak nucleophile to the fullerenyl cation electrophile. A monoarylated fullerene, (2-methylthiophenyl)hydro[60]fullerene, C60ArH (Ar = C6H4-SMe-2 and so on; four derivatives) was subjected to deprotonation with KOtBu to form a fullerenyl anion ArC60-, followed by oxidation using I2 to generate a fullerenyl cation ArC60+, leading to intramolecular demethylative cyclization via fullerene cation-S interaction to the product. Electrochemical and computational studies revealed slightly narrower band gap of this compound than usual fullerene derivatives because of the relatively high-lying HOMO of the fused thieno moiety.

Synthesis of Benzothieno[60]fullerenes through Fullerenyl Cation Intermediates

Benzothieno[60]fullerenes were synthesized using fullerenyl cations as key intermediates. The reaction proceeded through a nucleophilic attack of the sulfur atom as a weak nucleophile to the fullerenyl cation electrophile. A monoarylated fullerene, (2-methylthiophenyl)hydro[60]fullerene, C60ArH (Ar = C6H4-SMe-2 and so on; four derivatives) was subjected to deprotonation with KOtBu to form a fullerenyl anion ArC60-, followed by oxidation using I2 to generate a fullerenyl cation ArC60+, leading to intramolecular demethylative cyclization via fullerene cation-S interaction to the product. Electrochemical and computational studies revealed slightly narrower band gap of this compound than usual fullerene derivatives because of the relatively high-lying HOMO of the fused thieno moiety.

METHOD FOR PRODUCING PHENOTHIAZINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for producing a phenothiazine derivative that has reduced limitations on the number of functional groups that can be arranged to it, prevents the occurrence of by-products, and secures high yields. SOLUTION: A method for producing a phenothiazine derivative includes the step of reacting a benzyne precursor with a compound represented by formula (A) (RA1-RA5 independently represent H, a hydroxy group or an organic group, RA1 and RA2, RA2 and RA3, RA3 and RA4 may together form, with an adjacent atom, a 5-8 membered ring; RA6 is H or an optionally substituted C1-C20 hydrocarbon group; X is a halogen atom). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Synthesis of diverse phenothiazines by direct thioamination of arynes with S-(o-bromoaryl)-S-methylsulfilimines and subsequent intramolecular BuchwaldHartwig amination

A facile method for the synthesis of diverse phenothiazines has been achieved by direct thioamination of aryne intermediates with S-(o-bromoaryl)-S-methylsulfilimines and subsequent intramolecular BuchwaldHartwig amination. Since various sulfilimines could be prepared easily by odorless copper-catalyzed ipso-thiolation of readily available o-bromoarylboronic acids followed by imination and hydrolysis, this approach enables the synthesis of a wide variety of multisubstituted phenothiazines.

A New Approach to Rapid Parallel Development of Four Neurokinin Antagonists. Part 4. Synthesis of ZD2249 Methoxy Sulfoxide

The manufacture of ZD2249 methoxy sulfoxide (1) using a new project approach is described. Research department processes were scaled up to 100 L if process safety and robustness were not compromised; other factors were treated according to the new approach. Using this strategy, we were able to manufacture a key intermediate on sufficient scale to support delivery of 1 kg quantities of bulk drug within 6 months of the start of lab work.

Phenyl heterocyclyl ethers

The invention relates to compounds of formula I

Design, synthesis, and SAR of tachykinin antagonists: Modulation of balance in NK1/NK2 receptor antagonist activity

Through optimization of compounds based on the dual NK1/NK2 antagonist ZD6021, it was found that alteration of two key regions could modulate the balance of NK1 and NK2 potency. Substitution of the 2-naphthalene position in analogues of ZD6021 resulted in increased NK1 potency and thus afforded NK1 preferential antagonists. Alterations of the piperidine region could then increase NK2 potency to restore dual NK1/NK2 selectivity. Through these efforts, three novel receptor antagonists from a single chemically related series were identified; two are dual NK1/NK2 antagonists, and the third is an NK1 preferential antagonist. In this paper, the factors affecting the balance of NK1 and NK2 selectivity in this series are discussed and the in vitro and in vivo properties of the novel antagonists are described.

2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity

Compounds of formula I, STR1 in which A is a 5 or 6 membered, fully unsaturated, carbocyclic or heterocyclic ring, B is a 5 or 6 membered, fully unsaturated, nitrogen containing heterocyclic ring, X is NR19, O or S, R19 is hydrogen or alkyl optionally substituted by --OCOR, n is 0 or 1, R3, R4, R5, R6, R7, R8, R9 and R10 have various significances, R1 and R2, are hydrogen or alkyl or together with the ring carbon atoms to which they are attached, form a benzene or pyridine ring, which ring carries substituents R15, R16, R17 and R18, R15, R16, R17 and R18, have various significances, with certain provisos are described. Processes for making the compounds and pharmaceutical formulations containing them, e.g. for the treatment of conditions including excess gastric acid secretion, are also described.