255052-05-2Relevant academic research and scientific papers
Dual Role of Pyrrolidine and Cooperative Pyrrolidine/Pyrrolidinium Effect in Nitrone Formation
Morales, Sara,Guijarro, Fernando G.,Alonso, Inés,García Ruano, José Luis,Cid, M. Belén
, p. 84 - 91 (2016/01/12)
The formation of nitrones by direct condensation between equimolecular amounts of N-substituted hydroxylamine hydrochlorides and aromatic or aliphatic aldehydes is efficiently promoted by pyrrolidine in a matter of minutes under very mild conditions in almost quantitative yields after a simple filtration through a short pad of silica gel. According to theoretical, spectroscopic, and experimental studies, this success is due to the ability of pyrrolidine to liberate the hydrochloride of the hydroxylamine and catalyze the reaction via iminium activation ion. Moreover, a cooperative pyrrolidine/pyrrolidinium chloride effect facilitates several steps of the catalytic cycle through proton transfer without hampering the nucleophilicity of the hydroxylamine by protonation.
Efficient combination of task-specific ionic liquid and microwave dielectric heating applied to synthesis of a large variety of nitrones
Valizadeh, Hassan
experimental part, p. 78 - 83 (2011/04/16)
Under mild microwave irradiation conditions and without any additional organic solvents, a large variety of nitrones were prepared in a weak Lewis base phosphinite task-specific ionic liquid (TSILOPPh2) in excellent yields. This catalytic TSIL was also re
Rapid, efficient, and room temperature synthesis of nitrones in excellent yields over MgO under solvent-free conditions
Valizadeh, Hassan,Dinparast, Leila
experimental part, p. 177 - 181 (2009/10/04)
A large variety of C-aryl and C-alkyl nitrones were synthesized within 0.5-15 min via the condensation of aldehydes with N-(methyl, phenyl, or t-butyl)hydroxylamines over MgO by hand-grinding with an agate mortar. These reactions were investigated under d
α-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation
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, (2008/06/13)
Disclosed are novel α-(2-hydroxyphenyl) nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
