255060-79-8

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 88784-91-2 (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride 
• 88082-68-2 (1R,2R)-1-amino-1-phenylpropan-2-ol 
• 280128-37-2 (S)-N-[(1R,2S,R_S)-1-phenyl-2-p-tolylsulfinylpropyl]-p-toluenesulfinamide 
• 280128-41-8 (1R,2S,R_S)-1-phenyl-2-p-tolylsulfinylpropylamine 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 4518-66-5 (1S,2S)-(-)-1-phenyl-1-propene oxide 
• 255060-78-7 (-)-(1R,2S)-1-azido-1-phenyl-2-propanol 
• 280128-45-2 tert-butyl N-[(1R,R_S)-1-phenyl-2-p-tolylsulfinylpropyl]carbamate 

Downstream Products

• 255060-80-1 (1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate 
• 255060-81-2 (1R,2R)-1--1-phenylpropan-2-ol 
• 88082-68-2 (1R,2R)-1-amino-1-phenylpropan-2-ol 

Relevant academic research and scientific papers

Enantioselective synthesis of cyclic sulfamidates by using chiral rhodium-catalyzed asymmetric transfer hydrogenation

Asymmetric transfer hydrogenation (ATH) of cyclic sulfamidate imines 4 and 9, using a HCO2H/Et3N mixture as the hydrogen source and well-defined chiral Rh catalysts (S,S)- or (R,R)-2, CpRhCl(TsDPEN), effectively produces the corresponding cyclic sulfamidates with excellent yields and enantioselectivities at room temperature within 0.5 h. ATH of 4,5-disubstituted imines 9, having preexisting stereogenic centers, is shown to take place with dynamic kinetic resolution.

Highly potent inhibitors of TNF-α production. Part II: Metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformationally f

Additions of Enantiopure α-Sulfinyl Carbanions to (S)-N-Sulfinimines: Asymmetric Synthesis of β-Amino Sulfoxides and β-Amino Alcohols

The addition of the lithium anions derived from (R)- and (S)-methyl and -ethyl p-tolyl sulfoxides to (S)-N-benzylidene-p-toluenesulfinamide provides an easy access route to enantiomerically pure β-(N-sulfinyl)amino sulfoxides. Stereoselectivity can be ach

3-[3-(piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists

Several 5-HT(ID/1B) receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT(1D)receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3-(piperidin-1-yl)propyl]indoles has been synthesized which has led to the identification of 80 (L-772,405), a high- affinity h5-HT(1D) receptor full agonist having 170-fold selectivity for h5- HT(1D) receptors over h5-HT(1B) receptors. L-772,405 also shows very good selectivity over a range of other serotonin and nonserotonin receptors and has excellent bioavailability following subcutaneous administration in rats. It therefore constitutes a valuable tool to delineate the role of h5-HT(1D) receptors in migraine. Molecular modeling and physical properties have been utilized to postulate the binding conformation of these compounds in the receptor cavity.