88784-91-2

Usage

Uses

Used in Pharmaceutical Industry:
(1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride is used as a research compound for studying its potential pharmacological effects, particularly as a central nervous system stimulant. Its chiral nature and optical activity make it a valuable tool in medicinal chemistry and drug development, where it can be used to investigate the stereoselectivity of biological processes and the development of enantiomer-specific drugs.
Used in Medicinal Chemistry:
(1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride is used as a starting material or intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties can be exploited to design and develop new drugs with improved efficacy, selectivity, and reduced side effects.
Used in Drug Development:
(1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride is used as a potential candidate for the development of new drugs targeting the central nervous system. Its stimulant properties may be harnessed to treat conditions such as attention deficit hyperactivity disorder (ADHD), narcolepsy, or as a cognitive enhancer. However, further research is needed to fully understand its safety, efficacy, and potential side effects before it can be used in clinical applications.

Upstream product

• 255060-78-7 (-)-(1R,2S)-1-azido-1-phenyl-2-propanol 
• 4518-66-5 (1S,2S)-(-)-1-phenyl-1-propene oxide 
• 638211-27-5 (R_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxy-1-phenyl-propyl)-amide 
• 133735-63-4 (S)-1-Phenyl-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-propylamine 

Downstream Products

• 255060-79-8 (1R,2S)-1-[N-(tert-butoxycarbonyl)amino]-1-phenylpropan-2-ol 
• 526217-23-2 N-[(1R,2S)-2-hydroxy-1-phenylpropyl]octanamide 
• 638211-38-8 (4R,5S)-5-methyl-4-phenyloxazolidin-2-one 
• 255060-80-1 (1R,2R)-1-[N-(tert-butoxycarbonyl)amino]-1-phenyl-2-propyl 4-nitrobenzoate 
• 255060-81-2 (1R,2R)-1--1-phenylpropan-2-ol 

Relevant academic research and scientific papers

Alkylsulphonamide Quinolines

Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositi

Stereoselective Synthesis of 1,2-Disubstituted β-Amino Alcohols by Nucleophilic Addition to N-tert-Butanesulfinyl α-Alkoxyaldimines

N-tert-Butanesulfinyl α-alkoxyaldimines are readily prepared from protected (S)-lactals without epimerization at the α-stereocenter. Addition of ethyl and phenyl Grignard reagents, as well as the titanium enolate of methyl acetate, to the N-tert-butanesul

3-[3-(piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists

Several 5-HT(ID/1B) receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT(1D)receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3-(piperidin-1-yl)propyl]indoles has been synthesized which has led to the identification of 80 (L-772,405), a high- affinity h5-HT(1D) receptor full agonist having 170-fold selectivity for h5- HT(1D) receptors over h5-HT(1B) receptors. L-772,405 also shows very good selectivity over a range of other serotonin and nonserotonin receptors and has excellent bioavailability following subcutaneous administration in rats. It therefore constitutes a valuable tool to delineate the role of h5-HT(1D) receptors in migraine. Molecular modeling and physical properties have been utilized to postulate the binding conformation of these compounds in the receptor cavity.

Amino-Alcohols, I: A Method for the Synthesis of Enantiomerically Pure 1,2-Aminoalcohols with erythro-Configuration

The synthesis of both enantiomers of norephedrine and norisoephedrine is described to present a method for the preparation of enantiomerically pure branched 1,2-aminoalcohols.In a one pot reaction enantiomerically pure cyanohydrins bearing an acetal protective group are subjected to Grignard-reaction followed by addition of lithium aluminium hydride.After deprotection the target compounds are obtained.