255064-08-5

Usage

Uses

Used in Pharmaceutical Industry:
6-BROMO-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its benzimidazole and carboxylic acid functional groups provide a foundation for creating new drugs and biologically active molecules, contributing to the development of innovative treatments and therapies.
Used in Organic Synthesis:
In the field of organic synthesis, 6-BROMO-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID is utilized as a building block for the creation of complex organic molecules. Its unique structure allows for a wide range of chemical reactions, enabling the synthesis of diverse compounds with potential applications in various industries.
Used in Drug Development:
6-BROMO-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID is employed as a starting material in drug development, where its properties can be leveraged to design and synthesize new pharmaceutical agents. Its presence in the molecular structure can influence the pharmacological properties of the resulting compounds, making it a valuable component in the development of novel therapeutics.
Used in Research and Development:
In research and development settings, 6-BROMO-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID serves as a valuable tool for exploring new chemical reactions and understanding the properties of benzimidazole-based compounds. Its reactivity and solubility in organic solvents make it an ideal candidate for studying the synthesis and modification of complex organic molecules.
Used in Chemical Intermediates Production:
6-BROMO-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID is used as a chemical intermediate in the production of various organic compounds. Its ability to participate in a range of chemical reactions makes it a useful precursor for the synthesis of other molecules with specific properties and applications.

InChI:InChI=1/C8H5BrN2O2/c9-4-1-5(8(12)13)7-6(2-4)10-3-11-7/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 255064-10-9 6-bromo-4-methyl-1H-benzo[d]imidazole 
• 64-18-6 formic acid 
• 76153-06-5 5-bromo-3-methylbenzene-1,2-diamine 

Relevant academic research and scientific papers

Benzimidazole derivatives and its preparation and pharmaceutical composition and use thereof

The invention relates to a novel benzimidazole derivative shown in the formula I, medicinal salt of the novel benzimidazole derivative, a preparation method of the novel benzimidazole derivative, a composition with one or more novel benzimidazole derivatives, and an application of the novel benzimidazole derivative in treatment of tumor diseases. See the formula in the specification.

Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT3 receptors

A new series of azabicyclic benzimidazole-4-carboxamides 2-21 and - carboxylates 22-30 were synthesized and evaluated for binding affinity at serotoninergic 5-HT3 and 5-HT4 receptors in the CNS. Most of the synthesized compounds exhibited high or very high affinity for the 5-HT3 binding site and low to no significant affinity for the 5-HT4 receptor. SAR observations indicated that a halogen atom at the 6-position and a nitro group at the 7-position of the benzimidazole ring is the best substitution pattern for 5-HT3 affinity and 5-HT3/5-HT4 selectivity, as well as no substitution in this ring. (S)-(-)-N-(Quinuclidin-3-yl)benzimidazole-4- carboxamides 2, 8, and 14 bound at central 5-HT3 sites with high affinity (K(i) = 2.6, 0.13, and 1.7 nM, respectively) and excellent selectivity over serotonin 5-HT4 and 5-HT(1A) receptors (K(i) > 1000-10000 nM). Furthermore, these new 5-HT3 receptor ligands were pharmacologically characterized as potent and selective 5-HT3 antagonists in the isolated guinea pig ileum (pA2 = 9.6, 9.9, and 9.1, respectively).