25515-47-3

Basic information

• Product Name: 4.2'.4'.6'-tetrahydroxy-3-methoxy-trans-chalcone
• Synonyms: 4.2'.4'.6'-tetrahydroxy-3-methoxy-trans-chalcone
• CAS NO: 25515-47-3
• Molecular Weight: 302.284
• Mol File: 25515-47-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4.2'.4'.6'-tetrahydroxy-3-methoxy-trans-chalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 4.2'.4'.6'-tetrahydroxy-3-methoxy-trans-chalcone(25515-47-3)
• EPA Substance Registry System: 4.2'.4'.6'-tetrahydroxy-3-methoxy-trans-chalcone(25515-47-3)

Safety Data

• Hazardous Substances Data: 25515-47-3(Hazardous Substances Data)

Upstream product

• 1290638-51-5 1-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)-3-(3-methoxy-4-(methoxymethoxy)phenyl)prop-2-en-1-one 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 121-33-5 vanillin 
• 790-16-9 4-benzoyloxy-3-methoxybenzaldehyde 

Downstream Products

• 480-19-3 isorhamnetin 
• 446-71-9 homoeriodictyol 
• 221362-76-1 (+)-(R)-homoeriodictyol 

Relevant articles and documents

A kind of A ring with methyl of [...] compound, preparation method and anti-inflammatory activity

The invention discloses a quinoid chalcone compound with a methyl group at an A ring, and a preparation method and anti-inflammatory activity thereof. The compound has a structure as shown in a general formula (I) which is described in the specification. The preparation method comprises the following steps: (1) synthesizing 2-hydroxy-4,6-dimethoxyacetophenone; (2) synthesizing 2'-hydroxy-4',6'-dimethoxychalcone derivative; (3) synthesizing 2',4',6'-trihydroxy chalcone derivative; and (4) synthesizing the quinoid chalcone compound with a methyl group at the A ring. The compound is simple to prepare and has obvious anti-inflammatory action.

Design, synthesis and antidepressant activity evaluation 2′-hydroxy-4′,6′-diisoprenyloxychalcone derivatives

In this study, 14 2′-hydroxy-4′,6′-diisoprenyloxychalcone compounds were synthesized and their antidepressant activities were evaluated using the forced swimming test. The pharmacological results showed that six compounds significantly reduced immobility times during the forced swimming test at a dose of 10 mg/kg, indicative of antidepressant activity. Among these, three compounds (4d, 4e, and 4g) exhibited better antidepressant activity, with reduced immobility time by 38.3, 34.0, and 27.4 %, respectively. For explanation of the putative mechanism of action, compounds 4e, 4g were tested in chemical induced models.

Synthesis and Biological Evaluation of 2,4,6-Trihydroxychalcone Derivatives as Novel Protein Tyrosine Phosphatase 1B Inhibitors

A series of 2,4,6-trihydroxychalcone derivatives were synthesized and identified as reversible and competitive protein tyrosine phosphatase (PTP) 1B inhibitors with IC50 values in the micromolar range. Compound 4a had the greatest in vitro inhibition activity against PTP1B (IC50=0.27± 0.01μm) and the best selectivity (6.9-fold) for PTP1B relative to T-cell protein tyrosine phosphatases. The compounds identified herein provide a foundation on which to design specific inhibitors of PTP1B and other PTPs.