25532-76-7 Usage
General Description
(2'S)-2',3',6',7'-Tetrahydro-2'β-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]indene]-3'α,6'β,7'α-triol is a complex chemical compound with a spiro-structured cyclopropane ring and multiple hydroxyl groups. It has a cyclopropane-1,5'-[5H]indene core and three hydroxyl groups at positions 3', 6', and 7' on the cyclopropane ring. The compound also contains a hydroxymethyl group at position 2', as well as three methyl groups at positions 2', 4', and 6' of the spiro ring. This chemical compound's structure suggests potential pharmaceutical or biological activity, but further research would be needed to fully understand its properties and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 25532-76-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,5,3 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 25532-76:
(7*2)+(6*5)+(5*5)+(4*3)+(3*2)+(2*7)+(1*6)=107
107 % 10 = 7
So 25532-76-7 is a valid CAS Registry Number.
25532-76-7Relevant articles and documents
Structure-Activity Relationships of Illudins: Analogs with Improved Therapeutic Index
McMorris, Trevor C.,Kelner, Michael J.,Wang, Wen,Estes, Leita A.,Montoya, Mark A.,Taetle, Raymond
, p. 6876 - 6883 (2007/10/02)
Illudin S and M are extremely toxic sesquiterpenes produced by Omphalotus illudens.At low pH they behave as bifunctional alkylating agents, but at physiological pH they do not react with oxygen or nitrogen nucleophiles.Illudins react spontaneously with sulfur nucleophiles, gluthathione or cysteine, at or slightly below pH 7, and toxicity to HL 60 cells can be modulated by altering glutathione levels in cells.Analogs of illudin M, e.g. the deoxy and, particularly, the dehydro derivatives, are less reactive to thiols and correspondingly less toxic to HL 60 cells than the parent compound.Dehydroilludin M has been found to be quite effective at inhibiting tumor growth in vivo at doses well tolerated at athymic nude mice.
