1149-99-1 Usage
Uses
Used in Anticancer Applications:
Illudin S is used as an anticancer agent for its potent activity against multi-drug resistant tumors. It is particularly effective against myeloid and T-lymphocyte leukemia cells, even in cases where the cells display resistance to other chemotherapeutic agents. Illudin S's unique DNA damage mechanism makes it a valuable compound in the fight against cancer.
Used in Pharmaceutical Research:
Illudin S is used as a research compound for understanding the mechanisms of DNA alkylation and cell cycle inhibition. Its unique mode of action provides insights into the development of new anticancer drugs and potential strategies for overcoming drug resistance in cancer treatment.
Used in Drug Development:
Illudin S is used as a lead compound in the development of new antitumor drugs. Its potent activity against multi-drug resistant tumors and unique DNA damage mechanism make it an attractive candidate for further research and development in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1149-99-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,4 and 9 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1149-99:
(6*1)+(5*1)+(4*4)+(3*9)+(2*9)+(1*9)=81
81 % 10 = 1
So 1149-99-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H20O4/c1-8-10-9(6-13(2,7-16)12(10)18)11(17)14(3,19)15(8)4-5-15/h6,12,16,18-19H,4-5,7H2,1-3H3/t12-,13+,14+/m1/s1
1149-99-1Relevant academic research and scientific papers
AFFINITY ILLUDOFULVENE CONJUGATES
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Paragraph 0346, (2021/05/29)
In an embodiment of the invention, a composition for treating a cell population comprises a medicant. The medicant moiety can be an illudofulvene analog. In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The affinity moiety can be an antibody, an antibody fragment, a receptor protein, a peptidic growth factor, an anti-angiogenic protein, a specific binding peptide, protease cleavable peptide, a glycopeptide, a peptide, a peptidic toxin, a protein toxin and an oligonucleotide. The affinity moiety can be covalently bound to the medicant via a linker.
Synthesis of [3H]-illudin S, [3H]-acylfulvene, [3H]and[14C]- hydroxymethylacylfulvene (MGI 114)
McMorris, Trevor C.,Yu, Jian,Herman, David M.,Kelner, Michael J.,Dawe, Robin,Minamida, Akira
, p. 279 - 285 (2007/10/03)
Tritiated derivatives of the toxic sesquiterpene illudin S (1) have been prepared by fermentation of Omphalotus illudens in the presence of [3H]- sodium acetate. [3H]-illudin S was converted to antitumor [3H]-acylfulvene (4) by treatment with dilute sulfuric acid. Antitumor [14C]- hydroxymethylacylfulvene (5) was best prepared by reacting acylfulvene with [14C]-paraformaldehyde in dilute sulfuric acid.
