25536-14-5

Upstream product

• 7148-07-4 1-pyrrolidinocyclopent-1-ene 
• 77202-08-5 4-methyl-1,2,3-triazine 
• 88499-81-4 methyl-6 (pentyn-4'-yl)-2 pyrimidone-4 
• 42997-49-9 2-methyl-6,7-dihydro-5H-[1]pyrindine-3-carboxylic acid ethyl ester 
• 930-91-6 2-hydroxymethylenecyclopentanone 
• 1201003-37-3 2-(but-3-ynyl)cyclopentanone oxime 
• 1201003-43-1 2-(4-(trimethylsilyl)but-3-ynyl)cyclopentanone oxime 
• 2867-59-6 2-aminobutanol 
• 96-41-3 Cyclopentanol 

Relevant academic research and scientific papers

A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of - Amino Alcohols and Secondary Alcohols

The ruthenium complex (8-(2-diphenylphosphinoethyl)aminotrihydroquinolinyl)(carbonyl)(hydrido)ruthenium chloride exhibited extremely high efficiency toward the coupling cyclization of -amino alcohols with secondary alcohols. The corresponding products, pyridine or quinoline derivatives, are obtained in good to high isolated yields. On comparison with literature catalysts whose noble-metal loading with respect to -amino alcohols reached 0.5-1.0 mol % for Ru and a record lowest of 0.04 mol % for Ir, the current catalyst achieves the same efficiency with a loading of 0.025 mol % for Ru. The mechanism of acceptorless dehydrogenative condensation (ADC) was proposed on the basis of DFT calculations; in addition, the reactive intermediates were determined by GC-MS, NMR, and single-crystal X-ray diffraction. The catalytic process is potentially suitable for industrial applications.

Synthesis of pyridines and pyrazines using an intramolecular hydroamination-based reaction sequence

A management issue! Various pyridines and pyrazines can be efficiently accessed from simple acyclic precursors using an intramolecular hydroamination/isomerization/aromatization sequence (see scheme). ρ-Toluenesulfonic acid (2 mol%) is used to catalyze this novel alkyne annulation, in which the oxime group allows for a subsequent redoxneutral aromatization step to occur.

1,2,3-Triazines,III. - Synthesis of N-Aminopyrazoles and their Oxidation to 1,2,3-Triazines. Molecular Structure of 1,2,3-Triazine

Oxidation of the N-aminopyrazoles 4a-i affords the 1,2,3-triazines 5a-i.Spectra and reactions - such as oxidation, reduction, and cycloaddition reactions - of some 1,2,3-triazines 5 are described.The X-ray analysis of 5a is presented.

Reactions de cyclisation de pentynyl-2 pyrimidones-4

Acetylenic amidines HCC-(CH2)n-C(=NH)NH2 give, by condensation with β-ketoesters, pyrimidones substituted on carbon 2 by an acetylenic chain.Two types of evolution are observed when compounds are heated without any catalyst.The minor route is a cyclization by attack on a triple bond by the amidic nitrogen atom.The main reaction is a cycloaddition involving the non activated triple bond and an azadienic system, leading to non isolated tricyclic intermediates which retrocyclize to stable bicyclic compounds.