255387-50-9Relevant articles and documents
Use of N-trifluoroacetyl-protected amino acid chlorides in peptide coupling reactions with virtually complete preservation of stereochemistry
Jass, Paul A.,Rosso, Victor W.,Racha, Saibaba,Soundararajan, Nachimuthu,Venit, John J.,Rusowicz, Andrew,Swaminathan, Shankar,Livshitz, Julia,Delaney, Edward J.
, p. 9019 - 9029 (2003)
The use of protected amino acid chlorides for peptide coupling reactions has long been avoided due to the extensive racemization that commonly occurs during either the acid chloride formation or the coupling reaction itself. Conditions are described which