25543-96-8Relevant academic research and scientific papers
Synthesis and antimicrobial activities of some polyphenol compounds by nano zno-tbab as a heterogeneous catalytic media
Ahmadinejad, Ali,Bargebid, Rahele,Khabnadideh, Soghra,Khalafi-Nezhad, Ali,Zamani, Leila,Zomorodian, Kamiar
, p. 203 - 211 (2021/03/19)
Introduction: Mannich reaction is a typical example of a three-component condensation reaction and the chemistry of Mannich bases has been the matter of search by researchers. Here, an efficient procedure for the synthesis of some new Mannich derivatives
The modified-Mannich reaction: Conversion of arylboronic acids and subsequent coupling with paraformaldehyde and amines toward the one-pot synthesis of Mannich bases and benzoxazines
Liu, Juan,Yuan, Gaoqing
supporting information, p. 1470 - 1473 (2017/03/23)
A modified Mannich reaction has been developed for the synthesis of Mannich bases and benzoxazines via the oxidative hydroxylation of arylboronic acids and subsequent coupling with paraformaldehyde and amines in one pot. This modified Mannich reaction is easily carried out to afford the target products in good to excellent yields and tolerates a variety of functional groups.
Regioselective mannich reaction of phenols under high pressure using dichloromethane as C1 unit
Matsumoto, Kiyoshi,Joho, Kouta,Mimori, Seisuke,Iida, Hirokazu,Hamana, Hiroshi,Kakehi, Akikazu
scheme or table, p. 1061 - 1067 (2009/06/28)
Regioselectivity in Mannich reaction of 4-, 3-, and 2-substituted phenols with typical heterocyclic amines are investigated under reaction conditions developed by us. Phenol and 4-alkyl, and 4-chlorophenols in the title reaction predominantly gave the corresponding 2-(aminomethyl)phenols, while 4-methoxyphenol afforded, in addition to the mono(aminomethyl)phenols, a considerable amount of the bis adducts. Peculiarly enough, 3-methylphenol with amines afforded 3-methyl-4-(aminomethyl)phenols whereas 2-methylphenol produced 2-methyl-6-(aminomethyl)phenols.
Eco-friendly synthesis of novel lariat ethers via mannich reaction under solventless conditions
Sharghi, Hashem,Khalifeh, Reza
, p. 1601 - 1614 (2008/09/17)
An expeditious solventless synthesis of novel lariat ethers using calcium oxide (CaO) via Mannich reaction are herein described. This methodology eliminates the use of excess of solvent during the course of reaction. The reaction time is brought down from hours to minutes (20-30 minutes) along with yield enhancement. The CaO powder can be reused up to three times after simple washing with acetone.
Synthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticals
Siu, Anna F. M.,Lambrecht, Richard M.,Shani, Jashovam,Pyne, Stephen G.,Kane-Maguire, Leon A. P.
, p. 711 - 729 (2007/10/03)
The non-steroidal anti-inflammatory agent 2-amino-methyl-4-tert-butyl-6-iodophenol hydrochloride (MK-447) and some of its analogues were labelled with 123I and tested in an inflamed rat-paw model. Even though MK-447 has a significant anti-inflammatory activity, and a 2.3 ratio for inflamed site over muscle, its usefullness for scintigraphic detection of inflammation is hindered by its high uptake in the skin. The kinetic resolution of diastereomeric products with chiral dienyl iron complexes was unsuccessful as the signals from the respective 1H and 13C NMR spectra were coincident.
