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25545-88-4

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25545-88-4 Usage

Description

4-Amino-1,2,4-triazolehydrochloride, also known as 1,2,4-Triazol-4-amine, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical agents. It is characterized by its unique chemical structure, which allows it to form essential bonds and interactions with other molecules, making it a versatile compound in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
4-Amino-1,2,4-triazolehydrochloride is used as an intermediate for the preparation of potent, selective, and orally active cyclooxygenase-2 (COX-2) inhibitors. These inhibitors are essential in the development of anti-inflammatory and pain-relieving medications, as they help to reduce inflammation and alleviate pain by targeting the specific enzyme responsible for the production of prostaglandins, which are involved in the inflammation process.
Additionally, 4-Amino-1,2,4-triazolehydrochloride is used to synthesize hydroxyphenacyl azoles and related azolium derivatives, which are known for their antifungal properties. These compounds are used in the development of antifungal agents to treat various fungal infections, such as athlete's foot, ringworm, and yeast infections. The antifungal agents derived from 4-Amino-1,2,4-triazolehydrochloride work by disrupting the fungal cell membrane and inhibiting the synthesis of essential fungal cell components, ultimately leading to the death of the fungal cells and clearing the infection.

Check Digit Verification of cas no

The CAS Registry Mumber 25545-88-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,5,4 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 25545-88:
(7*2)+(6*5)+(5*5)+(4*4)+(3*5)+(2*8)+(1*8)=124
124 % 10 = 4
So 25545-88-4 is a valid CAS Registry Number.
InChI:InChI=1/C2H4N4/c3-6-1-4-5-2-6/h1-2H,3H2

25545-88-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name [4-amino-1,2,4-triazolium][Cl]

1.2 Other means of identification

Product number -
Other names 4-AMINO-1,2,4-TRIAZOLE HCL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25545-88-4 SDS

25545-88-4Upstream product

25545-88-4Downstream Products

25545-88-4Relevant articles and documents

Pairing heterocyclic cations with closo-dodecafluorododecaborate (2-): Synthesis of binary heterocyclium(1+) salts and a Ag4(heterocycle) 84+ salt of B12F122-

Belletire, John L.,Schneider, Stefan,Shackelford, Scott A.,Peryshkov, Dmitry V.,Strauss, Steven H.

, p. 925 - 936 (2011)

Eight binary salts that pair triazolium(1+), imidazolium(1+), pyrimidinium(1+), or purinium(1+) cations with the icosahedral closo-dodecafluorododecaborate(2-) anion (B12F12 2-) were synthesized using open-air benchtop metathesis reactions in water or acetonitrile. The scale of the reactions varied from just milligrams to nearly one gram of the K2B12F12 starting material. Other reaction conditions, the scope of the reaction, and the solubilities for the new salts are discussed. Five [heterocyclium] 2[B12F12] salts, which were obtained in yields ranging from 84% to 99%, displayed significantly higher densities than the corresponding previously reported analogous [heterocyclium]2[B 12H12] and [heterocyclium][CB11H12] salts. A ninth high-density salt consisted of B12F12 2- paired with a complex Ag4(triazole)8 4+ cation. The structures of eight of the nine new compounds were determined by single-crystal X-ray diffraction analysis. The density of five [heterocyclium]2[B12F12] salts was found to increase approximately linearly as the distance between the five-membered-ring heterocyclium(1+) cation centroids decreased. This work demonstrates additional flexibility for the rational design of ionic structures with predictable properties, which will ultimately permit the tailoring of ingredient-response behavior.

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