25557-39-5Relevant articles and documents
Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic-like activity
Bojarski, Andrzej J.,Paluchowska, Maria H.,Duszynska, Beata,Bugno, Ryszard,Klodzinska, Aleksandra,Tatarczynska, Ewa,Chojnacka-Wojcik, Ewa
, p. 1391 - 1402 (2006)
Introduction of 1,4-disubstituted cyclohexane ring in the structure of flexible long chain arylpiperazines resulted in linearly constrained, potent serotonin (5-HT)1A ligands. In order to trace structure-intrinsic activity relationships in this
Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand
Awadallah, Fadi M.,Mueller, Franziska,Lehmann, Jochen,Abadi, Ashraf H.
, p. 5811 - 5818 (2007)
The preparation of some lactam (cyclic amide) derivatives bearing various phenylpiperazinylbutyl side chains attached to the amide nitrogen together with their dopamine receptor affinity study is described. The synthesis of the target compounds involved t
Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-ht7/5-ht1a receptor selectivity
Medina, Rocío A.,Sallander, Jessica,Benhamú, Bellinda,Porras, Esther,Campillo, Mercedes,Pardo, Leonardo,López-Rodríguez, María L.
experimental part, p. 2384 - 2392 (2010/03/03)
We report the synthesis of a new set of compounds of general structure I (1-20) with structural modifications in the pharmacophoric elements of the previously reported lead UCM-5600. The new derivatives have been evaluated for binding affinity at 5-HTsub
