25576-40-3 Usage
Uses
Different sources of media describe the Uses of 25576-40-3 differently. You can refer to the following data:
1. A potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB0,+
2. Butyryl-L-carnitine may be used as an analytical reference standard for the separation and identification of underivatized butyryl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). It may also be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography-based techniques.
Definition
ChEBI: An optically active form of O-butanoylcarnitine having L-configuration.
General Description
Butyryl-L-carnitine is a naturally occurring compound belonging to the acylcarnitine class of compounds as listed in the human metabolome database (HMBD). These compounds are reported to be used as biomarkers in the diagnosis of carnitine deficiency. It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.
Biochem/physiol Actions
Butyrylcarnitine is elevated in patients with Acyl-CoA dehydrogenase, short-chain (SCAD) deficiency, in infants with acute acidosis and generalized muscle weakness and in middle-aged patients with chronic myopathy localized in muscle; very long chain Acyl-CoA dehydrogenase deficiency, and celiac disease.
Check Digit Verification of cas no
The CAS Registry Mumber 25576-40-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,5,7 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 25576-40:
(7*2)+(6*5)+(5*5)+(4*7)+(3*6)+(2*4)+(1*0)=123
123 % 10 = 3
So 25576-40-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H21NO4/c1-5-6-11(15)16-9(7-10(13)14)8-12(2,3)4/h9H,5-8H2,1-4H3/t9-/m1/s1
25576-40-3Relevant articles and documents
Differentiation of Isomeric Acylcarnitines Using Tandem Mass Spectrometry
Gaskell, Simon, J.,Guenat, Christian,Millington, David S.,Maltby, David A.,Roe, Charles R.
, p. 2801 - 2805 (2007/10/02)
Tandem mass spectrometry, using a four-sector instrument, has been used to distinguish isomeric acylcarnitines.Collisional activation of MH+ ions (or of acylcarnitine methyl ester cations) induces fragmentations of the acyl moieties, yielding daughter ions with relative abundances characteristic of individual isomers.Direct analyses of crude urine samples from children with metabolic disorders enable unequivocal identification of individual acylcarnitines, thus contributing to the characterization of the disorder.
