2558-28-3

Usage

Uses

Used in Fragrance Industry:
E-ALPHA-(4-FLUOROPHENYL)CINNAMONITRILE& is used as a fragrance ingredient for its pleasant scent, particularly in the manufacturing of perfumes and cosmetics.
Used in Pharmaceutical Industry:
E-ALPHA-(4-FLUOROPHENYL)CINNAMONITRILE& serves as an intermediate in the synthesis of pharmaceuticals, contributing to the development of various medicinal compounds.
Used in Agrochemical Production:
E-ALPHA-(4-FLUOROPHENYL)CINNAMONITRILE& has potential applications in the production of agrochemicals, playing a role in the creation of agricultural products.
Used in Polymer Additives Industry:
E-ALPHA-(4-FLUOROPHENYL)CINNAMONITRILE& is utilized in the production of polymer additives, enhancing the properties of various polymers for different applications.
Used in Other Industrial Products:
E-ALPHA-(4-FLUOROPHENYL)CINNAMONITRILE& also finds use in the manufacturing of other industrial products, highlighting its versatility in multiple chemical processes.

InChI:InChI=1/C15H10FN/c16-15-8-6-13(7-9-15)14(11-17)10-12-4-2-1-3-5-12/h1-10H/b14-10+

Upstream product

• 459-22-3 4-fluorophenylacetonitrile 
• 100-52-7 benzaldehyde 
• 352-32-9 p-fluorotoluene 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 100-51-6 benzyl alcohol 

Downstream Products

• 67958-52-5 2-(4-fluorophenyl)-3-phenylpropanenitrile 

Relevant academic research and scientific papers

Switchable Cobalt-Catalyzed α-Olefination and α-Alkylation of Nitriles with Primary Alcohols

The first switchable α-olefination and α-alkylation of nitriles with primary alcohols catalyzed by a well-defined base transition-metal Co complex was presented. A broad variety of nitriles and primary alcohols are selectively and efficiently converted to the corresponding products by this method. It is noteworthy that the transformation is environmentally benign and atom efficient with H2and H2O being the sole byproducts.

Dialkylamino cyclopentadienyl ruthenium(II) complex-catalyzed α-alkylation of arylacetonitriles with primary alcohols

Aminocyclopentadienyl ruthenium complexes, [(η5-C 5H4NMe2)Ru(PPh3)2(CH 3CN)]+BF4- and [(η5- C5H4NEt2)Ru(PPh3) 2(CH3CN)]+BF4-, are moderately active catalysts for α-alkylation of arylacetonitriles with primary alcohols; on the other hand, the analogous unsubstituted cyclopentadienyl ruthenium complex [(η5-C5H 5)Ru(PPh3)2(CH3CN)] +BF4- shows very low catalytic activity. On the basis of experimental results and theoretical calculations, rationalization for the much higher catalytic activity of the aminocyclopentadienyl complexes over that of the unsubstituted Cp complex is provided. In the catalytic systems with the former, it is possible to regenerate the active solvento complexes via protonation of the metal hydride intermediates and subsequent ligand substitution; this process is, however, very nonfacile in the catalytic system with the latter. The Royal Society of Chemistry 2010.

Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

We report on a series of α-substituted-β-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described.