255826-39-2

Upstream product

• 100-39-0 benzyl bromide 
• 255826-38-1 3-bromo-4-{[(tert-butyl)(dimethyl)silyl]oxy}-5-methoxyphenol 
• 255826-37-0 formic acid 4-(tert-butyldimethylsilanyloxy)-3-bromo-5-methoxyphenyl ester 
• 255826-36-9 3-bromo-4-{[(tert-butyl)(dimethyl)silyl]oxy}-5-methoxybenzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 

Downstream Products

• 255826-41-6 4-Benzyloxy-2-bromo-6-methoxyphenyl toluene-p-sulfonate 
• 255826-45-0 7-benzyloxy-4,5-dimethoxynaphthalen-1-yl acetate 
• 184110-34-7 7-benzyloxy-4,5-dimethoxynaphthalen-1-ol 
• 255826-40-5 4-Benzyloxy-2-bromo-6-methoxyphenol 

Relevant academic research and scientific papers

Complementary diastereoselectivity in the intermolecular addition of titanium and magnesium naphtholates to asymmetric lactaldehydes

Addition of 7-benzyloxy-4,5-dimethoxy-1-naphthol 3 as its triisopropoxytitanium naphtholate to (2R, 1′R or S)-2-(1′-ethoxyethoxy)propanal 4 afforded solely (15, 2R, 1″R or S)-1-(7′-benzyloxy-4′,5′-dimethoxy-1′-hydroxy-2′- naphthyl)-2-(1″-ethoxyethoxy)propan-l-ol 5, being the erythro product arising from anti addition. Complementary reaction of the naphthol 3 as its bromomagnesium naphtholate with aldehyde 4 gave rise solely to the alternative (1R, 2R, 1″R or S) diastereomer 6. The naphthol 3 was prepared through the completely regioselective addition of 2-methoxyfuran 9 to 5-benzyloxy-3-methoxydehydrobenzene 8. This differentially protected bisalkoxybenzyne was conveniently prepared from vanillin. The Royal Society of Chemistry 1999.