255826-65-4Relevant articles and documents
Promoting Frustrated Lewis Pairs for Heterogeneous Chemoselective Hydrogenation via the Tailored Pore Environment within Metal–Organic Frameworks
Niu, Zheng,Zhang, Weijie,Lan, Pui Ching,Aguila, Briana,Ma, Shengqian
supporting information, p. 7420 - 7424 (2019/04/27)
Frustrated Lewis pairs (FLPs) have recently been advanced as efficient metal-free catalysts for catalytic hydrogenation, but their performance in chemoselective hydrogenation, particularly in heterogeneous systems, has not yet been achieved. Herein, we demonstrate that, via tailoring the pore environment within metal–organic frameworks (MOFs), FLPs not only can be stabilized but also can develop interesting performance in the chemoselective hydrogenation of α,β-unsaturated organic compounds, which cannot be achieved with FLPs in a homogeneous system. Using hydrogen gas under moderate pressure, the FLP anchored within a MOF that features open metal sites and hydroxy groups on the pore walls can serve as a highly efficient heterogeneous catalyst to selectively reduce the imine bond in α,β-unsaturated imine substrates to afford unsaturated amine compounds.
Taxoid anti-tumor agents and pharmaceutical compositions thereof
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, (2008/06/13)
Pharmaceutical compositions, methods of administration, and methods of treatment of cancer with new generation taxoids, of formulas (I) and (II), and derivatives thereof, are described: 1
Taxoid anti-tumor agents and pharmaceutical compositions thereof
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, (2008/06/13)
This invention relates to a taxoid of the formula (I): STR1 wherein R1 is a C3 -C5 alkyl or alkenyl or trifluoromethyl radical; R2 is a C3 -C5 branched alkyl radical; R3 and Rsu