255833-41-1

Basic information

• Product Name: benzoic acid, 4-[[5-phenyl-4-(trifluoromethyl)-2-thiazolyl
• Synonyms: 4-{[5-phenyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}benzoic acid;benzoic acid, 4-[[5-phenyl-4-(trifluoromethyl)-2-thiazolyl;4-[[5-phenyl-4-(trifluoromethyl)-2-thiazolyl]amino]benzoic acid;4-[[5-phenyl-4-(trifluoromethyl)thiazol-2-yl]amino]benzoic acid
• CAS NO: 255833-41-1
• Molecular Formula: C17H11F3N2O2S
• Molecular Weight: 364.3416496
• Mol File: 255833-41-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzoic acid, 4-[[5-phenyl-4-(trifluoromethyl)-2-thiazolyl(CAS DataBase Reference)
• NIST Chemistry Reference: benzoic acid, 4-[[5-phenyl-4-(trifluoromethyl)-2-thiazolyl(255833-41-1)
• EPA Substance Registry System: benzoic acid, 4-[[5-phenyl-4-(trifluoromethyl)-2-thiazolyl(255833-41-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 255833-41-1(Hazardous Substances Data)

Usage

Uses

4-{[5-Phenyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}benzoic Acid can be used as a pharmacological enhancer of the Orai1 Ca2+ Channel to finetune physiological properties for Orai1 in smooth and skeletal muscles.

Upstream product

• 7366-56-5 4-thioureidobenzoic acid 
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• 147729-81-5 2-methoxy-2-trifluoromethyl-3-phenyloxirane 
• 147729-82-6 2-isopropoxy-2-trifluoromethyl-3-phenyloxirane 

Relevant articles and documents

Formation of thiazoles by reaction of 2-alkoxy-2-trifluoromethyl-3-phenyloxiranes with thioureas

Reactions of 2-alkoxy-2-trifluoromethy-3-phenyloxiranes with N-arylthioureas involve α-opening of the oxirane ring with formation of 2-arylamino-4-trifluoromethyl-5-phenylthiazoles. Reactions of 2-alkoxy-2-trifluoromethyl-3-phenyloxiranes with N,N′-diphenylthiourea and N,N′-ethylenethiourea stop at the stage of formation of the corresponding hydroxytetrahydrothiazoles. The same products are formed by reactions of N,N′-diphenylthiourea and N,N′-ethylenethiourea with α-bromobenzyl trifluoromethyl ketone. The transformation of 2-alkoxyoxiranes into thiazoles is a new version of the Hantzsch synthesis.