395-15-3

Upstream product

• 492-16-0 2-phenyl-2-trifluoroacetyl-acetonitrile 
• 15853-35-7 benzyltriphenylphosphonium cation 
• 122982-74-5 4-((E)-2-Phenyl-1-trifluoromethyl-vinyl)-morpholine 
• 123007-80-7 (Z)-4-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)morpholine 
• 122977-61-1 trifluoromethyl-1 trimethylsilyloxy-2 styrene 
• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 
• 16721-45-2 triphenyl(phenylmethylene)phosphorane 

Downstream Products

• 578-88-1 1,1,1-trifluoro-3-methoxy-3-phenyl-2-propanone 
• 147729-81-5 2-methoxy-2-trifluoromethyl-3-phenyloxirane 
• 147729-82-6 2-isopropoxy-2-trifluoromethyl-3-phenyloxirane 
• 322-01-0 rac-3,3,3-trifluoro-2-hydroxy-1-phenylpropan-1-one 
• 255833-41-1 4-((5-phenyl-4-(trifluoromethyl)thiazol-2-yl)amino)benzoic acid 
• 255833-34-2 5-phenyl-4-(trifluoromethyl)-1,3-thiazole-2-amine 
• 389-59-3 1,2-diacetoxy-3,3,3-trifluoro-1-phenyl-propene 

Relevant academic research and scientific papers

Halogenation of 1-trifluoromethyl enamines: A new and efficient synthesis of α-bromo-and α-iodo-trifluoromethyl ketones

Treatment of the 1-trifluoromethyl enamines 1a-d with bromine or iodine results in the formation of the corresponding iminium salts. Treatment of any of these salts with methanol results in the formation of the corresponding α-halo-trifluoromethyl ketones

NOUVELLE SYNTHESE DE TRIFLUOROMETHYLCETONES ET D' α-BROMO TRIFLUOROMETHYLCETONES

We report a new method for the preparation of trifluoromethylketones, as an alternative to the use of organometallics.The condensation of phosphonium ylides with trimethylsilyl trifluoroacetate provides silyloxy enol ethers whose hydrolysis leads to trifluoromethylketones.Bromation of the same silyloxy enol ether is also a convenient preparation of α-bromo trifluoromethylketone.