255835-91-7

Basic information

• Product Name: 4-(2,6-dimethylphenyl)morpholine
• Synonyms: 4-(2,6-dimethylphenyl)morpholine
• CAS NO: 255835-91-7
• Molecular Formula: C12H17NO
• Molecular Weight: 191.26948
• Mol File: 255835-91-7.mol
• Article Data: 33

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2,6-dimethylphenyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,6-dimethylphenyl)morpholine(255835-91-7)
• EPA Substance Registry System: 4-(2,6-dimethylphenyl)morpholine(255835-91-7)

Safety Data

• Hazardous Substances Data: 255835-91-7(Hazardous Substances Data)

Usage

Description

4-(2,6-dimethylphenyl)morpholine is a morpholine derivative with a molecular formula C12H17NO. It is characterized by a morpholine ring combined with a 2,6-dimethylphenyl group. This chemical compound has a diverse range of applications in various industries, including pharmaceuticals, agriculture, and manufacturing, due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
4-(2,6-dimethylphenyl)morpholine is used as a building block for the synthesis of various biologically active molecules and pharmaceuticals. Its unique chemical structure and properties make it a promising candidate for the development of new drugs.
Used in Agricultural Industry:
4-(2,6-dimethylphenyl)morpholine is used as a precursor in the development of new pesticides. Its chemical properties allow it to be incorporated into compounds that can effectively control pests and protect crops.
Used in Manufacturing Industry:
4-(2,6-dimethylphenyl)morpholine is used as an intermediate in the production of various useful compounds. Its versatility and unique structure make it a valuable component in the synthesis of a wide range of products.
Overall, 4-(2,6-dimethylphenyl)morpholine plays a significant role in the field of chemical research and has promising potential in various industrial applications.

Upstream product

• 110-91-8 morpholine 
• 6781-98-2 2,6-dimethyl-1-chlorobenzene 
• 576-22-7 2-Bromo-m-xylene 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 1003858-51-2 2-(2,6-dimethylphenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 576-26-1 2.6-dimethylphenol 
• 252573-81-2 2,5-dimethylphenyl nonaflate 

Relevant articles and documents

Pd-NHC catalyzed biaryl coupling by direct C-H activationA novel strategy for the synthesis of dibenzocyclooctane lignans

Cross-coupling reactions, such as Buchwald-Hartwig arylamination and direct intramolecular biaryl coupling by C-H activation, were carried out using various Palladium-N-heterocyclic carbenes (Pd-NHC) as catalysts. The yields were good to excellent. The la

Large-steric-hindrance N-heterocyclic carbene palladium complex, preparation method and application thereof, and synthesis method of sonidegib based on large-steric-hindrance N-heterocyclic carbene palladium complex

The invention belongs to the technical field of organic synthesis and chemical catalysis, and discloses a large-steric-hindrance N-heterocyclic carbene palladium complex, a preparation method thereof,an application of the complex in efficient catalysis of a C-N coupling reaction under a room-temperature air condition, and a synthesis method of sonidegib based on the complex. According to the large-steric-hindrance N-heterocyclic carbene palladium complex, diphenyl imidazole serves as a main ligand framework, functionalized allyl serves as an auxiliary ligand, the functionalized allyl is introduced beside a metal center of a catalyst to serve as an auxiliary ligand, the catalytic activity and stability are remarkably improved, the large-steric-hindrance N-heterocyclic carbene palladium complex can be applied to efficient catalysis of a CN coupling reaction, particularly, the CN coupling reaction can be efficiently catalyzed under the room temperature condition, and the yield can reachup to 99%. The invention also provides a method for synthesizing sonidegib by taking aryl/aliphatic amine and aryl chloride as reactants and a three-step method at room temperature under the catalysisof a palladium catalytic system, the synthetic method has few steps, and the total yield can reach 74.5%.

An easily available N-heterocyclic carbene–palladium(II) catalyst for Buchwald–Hartwig amination of aryl chlorides

Abstract: An easily available N-heterocyclic carbene–palladium(II) complex was found to be an efficient catalyst for the Buchwald–Hartwig amination of aryl chlorides. Both secondary and primary amines were tolerated under the same reaction conditions. Under the optimal conditions, all reactions proceeded successfully to give the desired products in good to high yields within hours. Graphical Abstract: [Figure not available: see fulltext.]