255893-56-2

Upstream product

• 5509-65-9 2,6-difluoroaniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 110-85-0 piperazine 
• 1489-53-8 1,2,3-trifluorobenzene 

Downstream Products

• 1254980-10-3 8-(trifluoromethyl)-3-(cyclopropylmethyl)-7-[(4-(2,6-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine 
• 1027492-64-3 {2-amino-4-[(4-(2,6-difluorophenyl)piperazin-1-yl)methyl]thiophen-3-yl}(4-chlorophenyl)methanone 
• 1355156-00-1 2-{3-(4-chlorobenzoyl)-4-([4-(2,6-difluorophenyl)piperazin-1-yl]methyl)thiophen-2-yl}-isoindole-1,3-dione 
• 1254980-23-8 8-chloro-3-cyclopropylmethyl-7-[(4-(2,6-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine 
• 475652-83-6 3-[4-(2,6-difluoro-phenyl)-piperazin-1-yl]-1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-propan-1-one 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS OF THEIR USE

Provided are agents capable of binding the KIX domain of CBP or MED15 to inhibit the binding between SREBP1 and the KIX domain of MED15 or CBP. Also provided are compositions containing the agents and methods of their use.

Microwave-assisted amination from fluorobenzenes without catalyst and strong base

A facile and versatile amination of fluorobenzenes has been developed in good to excellent yields under microwave irradiation in N-methylpyrrolidinone (NMP) without strong base and catalyst. The presence of additional halogen atom(s) enhanced the leaving ability of fluorine and meta fluorine gave higher activation than the ortho. It is remarkable that 1,2,3-trifluorobenzene, 1,2,4-trifluorobenzene and 1,2,4,5-tetrafluorobenzene can produce the regioselective mono-substituted products.

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes.

A series of novel 3-substituted-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes in order to improve the in vitro and in vivo activity of our prototype 3-[4-(3-chlorophenyl)-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propene (2) were synthesized and evaluated by assays of growth inhibition against several tumor cell lines in vitro and antitumor activity against some tumor models when dosed both intraperitoneally and orally in vivo. Compounds 7a and 7e, the 3,5-difluorophenyl and 3,5-dichlorophenyl analogues of 2, respectively, showed significantly more potent cytotoxicity than 2 in vitro and potent antitumor activities without causing decrease of body temperature related to side effects.