255895-85-3Relevant academic research and scientific papers
Enantioselective Synthesis of Chiral Indane Derivatives by Rhodium-Catalyzed Addition of Arylboron Reagents to Substituted Indenes
Umeda, Moeko,Noguchi, Hikaru,Nishimura, Takahiro
, p. 9597 - 9602 (2020)
Rhodium-catalyzed asymmetric addition of arylboron reagents to indene derivatives proceeded to give 2-arylindanes in good yields with high enantioselectivity. Deuterium-labeling experiments indicated that the present reaction involved a 1,4-Rh shift from an initially formed benzylrhodium to an arylrhodium intermediate before protonation leading to the corresponding addition product. The asymmetric addition was also successful for acenaphthylene, which has a similar skeleton to indene, where it was found that the benzylrhodium intermediate underwent direct protonation without the 1,4-Rh shift.
THERAPEUTIC AGENTS
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Paragraph 0139; 0155, (2014/11/11)
The invention provides well-defined compounds that are either EP2 agonists, EP4 agonists, or mixed EP2/EP4 agonist. The compounds are useful for treating a variety of pathological conditions associated with acti
Polycyclic thiazol-2-ylidene amines, processes for their preparation and their use as medicaments
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, (2008/06/13)
The invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically tolerated salts and physiologically functional derivatives. Polycyclic thiazolidin-2-ylidene amines of the formula I, in which the radicals have the stated meanings
Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals
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, (2008/06/13)
Polycyclic thiazolidin-2-ylidene amines and their physiologically tolerable salts and physiologically functional derivatives of the formula I in which the radicals have the meanings indicated, and their physiologically tolerable salts and a process for their preparation are described. The compounds are suitable, for example, as anorectics.
