25593-72-0

Basic information

• Product Name: N-[3-[4-(3-aminopropylamino)butylamino]propyl]acetamide
• Synonyms: N-[3-[4-(3-aminopropylamino)butylamino]propyl]acetamide;N1-Acetylspermine;N'-acetylspermine;Ac-Spm;N-(3-Aminopropyl)-N'-(3-(acetylamino)propyl)-1,4-butanediamine;N-Acetyl-4,9-diazadodecane-1,12-diamine
• CAS NO: 25593-72-0
• Molecular Formula: C₁₂H₂₈N₄O
• Molecular Weight: 244.38
• Mol File: 25593-72-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 442.9°C at 760 mmHg
• Flash Point: 221.7°C
• Appearance: /
• Density: 0.962g/cm³
• Vapor Pressure: 4.84E-08mmHg at 25°C
• Refractive Index: 1.479
• PKA: 16.38±0.46(Predicted)
• CAS DataBase Reference: N-[3-[4-(3-aminopropylamino)butylamino]propyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-[4-(3-aminopropylamino)butylamino]propyl]acetamide(25593-72-0)
• EPA Substance Registry System: N-[3-[4-(3-aminopropylamino)butylamino]propyl]acetamide(25593-72-0)

Safety Data

• Hazardous Substances Data: 25593-72-0(Hazardous Substances Data)

Usage

Definition

ChEBI: An acetylspermine carrying an acetyl group at position N1.

InChI:InChI=1/C12H28N4O/c1-12(17)16-11-5-10-15-8-3-2-7-14-9-4-6-13/h14-15H,2-11,13H2,1H3,(H,16,17)

Upstream product

• 71-44-3 Spermine 
• 604-68-2 α-D-glucopyranose peracetylate 

Downstream Products

• 124-20-9 N-(3-aminopropyl)-1,4-diaminobutane 
• 73323-68-9 N-acetyl-3-aminopropanaldehyde 
• 109-76-2 Trimethylenediamine 

Relevant articles and documents

The number and distances of positive charges of polyamine side chains in a series of perylene diimides significantly influence their ability to induce G-quadruplex structures and inhibit human telomerase

We have synthesized eight polyamine perylene diimides to conjugate the efficiency of perylene derivatives in stabilizing G-quadruplex structures and the polyamines' biological activity, due to specific interactions with different DNA domains. Our study was carried out by investigating the ability of these derivatives to induce inter- and intramolecular G-quadruplex structures by polyacrylamide gel electrophoresis (PAGE) and to inhibit telomerase in a modified TRAP assay. The two properties appear to be satisfactorily correlated and they show that the number and distances of positive charges in the side chains dramatically influence both these features. Although our previous studies on perylene derivatives with mono-positively charged side chains indicated that self assembly in aqueous solution leads to a major efficiency, the result observed with the spermine derivative suggests that a too strong aggregation is unfavourable, because it determines a lower solubility of the compounds.